April 14, 2011 - EuroPharma’s BCM-95 Curcumin Superior in Absorption
EuroPharma’s BCM-95 Curcumin Superior in Absorption
Comparison analysis shows 200% the Curcuminoid Serum Levels of Curcumin Phytosome, and 700% That of Plain Curcumin
GREEN BAY, WI April 14, 2011 – As curcumin continues to grow in both numbers of published studies and product sales, the herbal product’s problems with absorption has increasingly become an area of focus. Today, results of a comparison analysis of curcumin products with enhanced absorption were announced. Researchers analyzed the difference in blood curcumin levels between BCM-95 Curcumin, Plain Curcumin, and Phytosome® form curcumin
“There is so much confusion out there regarding curcumin,” states Ajay Goel. Ph.D., Director of Epigenetics and Cancer Prevention at the Gastrointestinal Research Center at Baylor University Medical Center in Dallas, TX. “People may be unaware that plain curcumin is hard to absorb. The focus of researchers has been to discover better strategies to enhance curcumin absorption that would also allow longer retention times and higher therapeutic levels of sustained curcumin in the blood. The consequence of this mad race to discover the best curcumin preparation available in the marketplace has led to misleading marketing claims comparing curcumin absorption to turmeric in some instances, and fuzzy math and statistics in interpreting studies on curcumin with special absorption systems. The two most important measures that support scientific logic remain: what levels of full-spectrum of curcuminoids can be detected in the blood, and how long do the curcuminoids remain in the blood stream within the therapeutic range.”
Two previously published human studies comparing BCM-95 curcumin to plain curcumin have shown a 7- fold increase in absorption and a 10-fold increase in single serum peak compared to plain curcumin.1a
When a recent study in the Journal of Natural Products on curcumin phytosome (marketed as Meriva® brand) absorption reported “29-fold” absorption, researchers decided to compare these results on a per mg basis. The curcumin phytosome is one part curcumin, two parts lecithin (phosphatidylcholine) and two parts cellulose. So there is less than 100 mg of actual curcumin in a 500 mg curcumin complex. In contrast, researchers in studies on BCM-95 determined that in each 500 mg of BCM-95 curcumin, there is more than 450 mg full-spectrum curcuminoids. This is 450% more curcumin content than the phytosome form.
In order to make a statistical comparison, researchers compared the average increase of curcumin in the blood stream following use of BCM-95 curcumin, curcumin phytosome and plain curcumin, as determined by published human absorption data. 1 Each 1 mg of BCM-95 curcumin = a 0.34 increase in curcumin in the bloodstream, measured as nanograms per gram (ng/g). Each 1 mg curcumin phytosome complex = 0.15 ng/g. Plain curcumin was less than 0.04 ng/g. The highest serum increase was seen with BCM-95 curcumin, which raised the blood levels of curcumin more than twice as much as the phytosome form.
Unfortunately, in the Cuomo et al study, a 29-foldincrease in absorption was not adjusted to accommodate for the fact that less than 1/5th of the curcumin phytosome is actually curcumin.
“In other words, 29 times a dime is not as good as 7 times a dollar. The multiplier may be larger, but the end result is less because the reference material is less,” explained Terry Lemerond, president of EuroPharma, Inc.
“I am also concerned about curcumin products focusing on one single member of the curcuminoid family. In my research, I have found that the most potent form of curcumin is one in which the full family of curcuminoids are represented in their natural arrangement, and trying to use a single curcuminoid away from the family may be much less effective,” states Dr. Goel.
In addition to a 6-month published2 human study on Alzheimer’s disease at the Chinese University of Hong Kong, BCM-95 curcumin is the subject of a current one year study on preventing progression of dementia in Alzheimer’s patients at Edith Cowan University in Australia. 3
Other studies have also utilized BCM-95 curcumin in investigating the results of this unique curcumin in other disease states. Studies either completed or in process include osteoarthritis, rheumatoid arthritis, depression, and studies on oral, cervical, and colon cancer.
EuroPharma, Inc. is the exclusive distributor of BCM-95® curcumin products in the U.S. through both the health food store and professional distribution channels. EuroPharma offers clinically proven and effective nutritional supplements and natural remedies that improve the health of America. Terry Lemerond, founder and president of EuroPharma, is well-known for innovation, as he is credited as the first to introduce glucosamine sulfate, standardized Ginkgo biloba, and the award winning natural pain product, Curamin®, to the U.S. natural products market. At EuroPharma, Our Passion is Your Health™. For more information on EuroPharma, visit www.EuroPharmaUSA.com
1. Based on a comparison of results reported in published scientific papers:
a. Antony B. A pilot cross-over study to evaluate human oral bioavailability of BCM-95, a novel bioenhanced preperation of curcumin. Ind J Pharm Sci. 2008:445-450.
b. Cuomo J. Comparative Absorption of a Standardized Curcuminoid Mixture and Its Lecithin Formulation. J Nat Prod. 2011 Mar 17.
2. Baum L, Lam C, Cheung S, et al. Six-Month Randomized Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients with Alzheimer’s Disease. Journal of Clinical Psychopharmacology, Vol 28, Number 1, Feb 2008 pg 110-114.
3. Martins R. Evaluation of the nutritional extract Bio-curcumin (BCM-95) to preserve cognitive functioning in a cohort of mild cognitively impaired (MCI) patients over 12 months. Edith Cowan University. Joondalup, Western Australia. Study in process.
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