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Evidence
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Adaptra™ - (formerly Daily Stress Relief)

This combination of four clinically tested herbal extracts helps promote energy, vitality, and stress resistance. Research suggests that their beneficial activity may be primarily through the prevention of negative stress responses (increase of nitric oxide production) and preserving cellular energy (ATP) production. Each herb in the formula is standardized to its key compound ensuring potency and benefits.*

Rhodiola (rosavins)

Rhodiola is particularly effective at reducing acute stress. In clinical tests of people in stressful occupations, rhodiola extract was shown to improve energy, reduce fatigue, and boost concentration, focus, and mental clarity.*1-3

Eleuthero (eleuthorosides)

A clinical trial of eleuthero found it to be effective at reducing physical response to chronic stress. Additional research has found the administration of eleuthero was associated with improved mental health, increased physical endurance, increased immune activity, and reduced cortisol levels.*4-6

Schisandra (schisandrins)

Schisandra reduces cortisol and protects the adrenal glands from the effects of stress, as well as increasing energy and stamina.*11,12  It has also been shown to support a natural anti-inflammatory response.*13  

Ashwagandha (withanolides)

Ashwagandha is an important remedy in Ayurvedic medicine, where it is used to promote physical and mental health and rejuvenate the body.  Research studies have found that ashwaghanda increases resistance to stress, including reducing plasma corticosterone levels and increasing antioxidant activity.*7,8  In men, administration of ashwagandha was associated with decreased stress and improved semen quality.*9,10  

References

1. Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009;75(2):105-12.

2. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000;7(5):365-71.

3. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000;7(2):85-9.

4. Cicero AF, Derosa G, Brillante R, Bernardi R, Nascetti S, Gaddi A. Effects of Siberian ginseng (Eleutherococcus senticosus maxim.) on elderly quality of life: a randomized clinical trial. Arch Gerontol Geriatr Suppl. 2004;(9):69-73

5. Asano K, Takahashi T, Miyashita M, et al. Effect of Eleutheroccocus senticosus Extract on Human Physical Working Capacity. Planta Med. 1986;52(3):175-7

6. Kimura Y, Sumiyoshi M. Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice. J Ethnopharmacol. 2004;95(2-3):447-53.

7. Bhattacharya SK, Muruganandam AV. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav. 2003;75(3):547-55.

8. Singh A, Naidu PS, Gupta S, Kulkarni SK. Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. J Med Food. 2002;5(4):211-20

9. Mahdi AA, Shukla KK, Ahmad MK, et al. Withania somnifera improves semen quality in stress-related male fertility. Evid Based Complement Alternat Med. 2009.

10. Ahmad MK, Mahdi AA, Shukla KK, et al. Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Fertil Steril. 2009.

11. Sun LJ, Wang GH, Wu B, et al. Effects of schisandra on the function of the pituitary-adrenal cortex, gonadal axis and carbohydrate metabolism in rats undergoing experimental chronic psychological stress, navigation and strenuous exercise. Zhonghua Nan Ke Xue. 2009;15(2):126-9.

12. Panossian A, Wikman G. Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine. J Ethnopharmacol. 2008;118(2):183-212.

13. Guo LY, Hung TM, Bae KH, et al. Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. Eur J Pharmacol. 2008;591(1-3):293-9

FAQ's

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Adaptra™ - (formerly Daily Stress Relief)

Q: Why should Adaptra be taken on an empty stomach?

Many experts feel that Rhodiola rosea is better absorbedon an empty stomach. However, if experiencing nausea or stomach upset when taking this product as recommended, Adaptra can be taken with a small amount of food.

Additional Health Information

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Adaptra™ - (formerly Daily Stress Relief)

Adaptra™ - (formerly Daily Stress Relief)

Adrenal Response and Daily Stress Relief*

Product Number: 20016 - 60 Capsules

Dietary Supplement

1 to 2 capsules daily, or as desired. For optimal results take on an empty stomach.

Adaptra™ is a potent adaptogen formula that fights stress and strengthens the body from within.

• Maximize Energy
• Relieve Stress
• Sharpen Memory and Concentration
• Promote Heart Health
• Enhance Physical Performance
• Optimize Weight Loss
• Promote Muscle Tone and Strength
• Enhance Sexual Function*

SUPPLEMENT FACTS

Serving Size: 1 capsule

Servings Per Container: 60 Amount/Serving Daily Value

Proprietary Formula

 750 mg **

Rhodiola (Rhodiola rosea) Root Extract standardized to contain >5% rosavins (rosavins and salidrosides), Eleuthero (Eleutherococcus senticosus) Root Extract standardized to contain >0.8% eleuthorosides, Ashwagandha (Withania somnifera) KSM-66® standardized to contain 5% withanolides, Schisandra (Schisandra chinensis) Extract standardized to contain >9% schisandrins

**Daily Value Not Established

Other Ingredients: vegetable cellulose capsules, magnesium stearate, silicon dioxide, cellulose powder

Contains no: sugar, salt, soy, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring or preservatives. It contains only natural ingredients. Color variations are normal.

KSM-66® is a registered trademark of lxoreal Biomed Pvt. Ltd.

If pregnant or nursing, consult a health care practitioner before using.

Made in the USA.

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Did You Know?

Adaptogenic plants, such as rhodiola and ashwagandha, help increase the body’s resistance to stress. Adaptogens are not toxic, they work in multiple pathways (non-specific) to defend against stress and increase energy, and they have a normalizing influence on the body.* Most of the adaptogenic herbs have a long history of use in Eastern medicine, including Ayurveda and Traditional Chinese Medicine. Eleuthero, ginseng, and astragalus are other examples of adaptogenic herbs. 

*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION.
THESE PRODUCTS ARE NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT DISEASE.

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The research articles and study abstracts that you are about to view in the EuroPharma USA Library were prepared by independent authors and researchers. They are being reproduced on this site in their entirety. No such article or study abstract is intended to promote a particular manufacturer or brand of dietary supplement. This information is not intended to replace the advice of your health care practitioner. If you have any medical conditions, or are taking any prescription or nonprescription medications, see your physician and discuss all aspects of your treatment before altering or discontinuing any course of therapy. Accordingly, individuals must necessarily assume responsibility for their own actions, safety, and health, and the company is not liable or responsible for any loss, injury, or damage allegedly arising from any information posted on this cite.

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