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Evidence
(How it Works)

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Arthocin®

How it Works:

Acetyl-11-Keto-beta-Boswellic Acid, or AKBA, is one of the most potent compounds in boswellia. However, its benefits can be partially blocked by another compound found in boswellia – beta boswellic acid. Researchers have found that by removing beta boswellic acid, the effectiveness of the boswellic extract is greatly increased.  Arthocin combines this unique extract with curcumin, devil’s claw, and gooseberry, three additional ingredients which help support joint mobility and health.*

Boswellia (BosPure®)
A unique extract, clinically tested BosPure® boswellia helps support healthy joint function. A compound, beta boswellic acid, which interferes with its beneficial activity, has been removed, greatly increasing the effectiveness of the extract.*1,2

Curcumin (BCM-95®)
Curcumin from turmeric, supports multiple pathways in the body.* The clinically-tested BCM-95® curcumin in this formula has up to 10 times greater absorption that standard curcumin extracts and has shown clinical support for joint health.*3-8

Devil’s Claw
Devil’s claw (Harpagophytum procumbens) is a low-growing perennial found in southern Africa. It is known by several common names, but called “devil’s claw” because of the hook-shaped “claws” on its fruit. Devil’s claw was very well-regarded among traditional practitioners in southern Africa, and was introduced into Europe by the mid-1900’s. The extract in Arthocin has been shown to increase hyaluronic acid synthesis in chondrocytes, which can improve joint lubrication, by up to 41%.*9-11

Indian Gooseberry
Indian gooseberry (Emblica officinalis) is also known as Amla, and has a long history of use in Ayurvedic practice. The extract in Arthocin is standardized to contain at least 35% total polyphenol content.*12,13

References

1. Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006;72(12):1100-16.

2. Poeckel D, Tausch L, Altmann A, Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid. Br J Pharmacol. 2005;146(4):514-24

3. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14(2):141-53.

4. Jacob A, Wu R, Zhou M, Wang P. Mechanism of the anti-inflammatory effect of curcumin: PPAR-gamma activation. PPAR Res. 2007;89369.

5. Benny B, Antony B. Bioavailability of Biocurcumax (BCM-95). Spice India. September, 2006:11-15.

6. Antony B, Merina B, Iyer VS, Judy N, Lennertz K, Joyal S. A pilot cross-over study to evaluate human oral bioavailability of BCM-95 CG (Biocurcumax™) a novel bioenhanced preparation of curcumin. Ind J Pharm Sci. 2008:445-449.

7. Chandran B, Goel A. A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis. Phytother Res. 2012 Mar 9. doi: 10.1002/ptr.4639.

 8. Antony B, Kizhakkedath R, Benny M, Kuruvilla B. Clinical Evaluation of an Herbal Formulation in the Management of Knee Osteoarthritis. Poster presentation. Presented at the Osteoarthritis Research Symposium Internationale (OARSI) Annual World Congress on Osteoarthritis, September 15-18, 2011. San Diego, CA.

9. Harpagophytum procumbens (devil's claw). Monograph. Altern Med Rev. 2008;13(3):248-52.

10. Huang TH, Tran VH, Duke RK, et al. Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation. J Ethnopharmacol. 2006;104(1-2):149-55.

11. Wegener T. Therapy of degenerative diseases of the musculoskeletal system with South African devil's claw (Harpagophytum procumbens DC). Wien Med Wochenschr. 1999;149(8-10):254-7

12. Asmawi MZ, Kankaanranta H, Moilanen E, Vapaatalo H. Anti-inflammatory activities of Emblica officinalis Gaertn leaf extracts. J Pharm Pharmacol. 1993;45(6):581-4.

13. Sumantran VN, Kulkarni A, Chandwaskar R, et al. Chondroprotective potential of fruit extracts of Phyllanthus emblica in osteoarthritis. Evid Based Complement Alternat Med. 2008;5(3):329-335.

FAQ's

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Arthocin®

Q: Can Arthocin® be taken with Curamin®?

Yes, both Arthocin and Curamin can be used together. Curamin is an excellent formula for providing immediate benefits, and Arthocin can be used long-term for daily maintenance.

Q: Why is the BosPure® in Arthocin® screened to reduce beta-boswellic acid?

While most boswellic acids are associated with positive benefits, beta-boswellic acid is pro-inflammatory. Keeping it to less than 5% doubles the effectiveness of BosPure® boswellia.

Q: What is the difference between Arthocin® and Dyflaminol™?

The combination and level of ingredients in Arthocin – especially given its high levels of Devil’s Claw and Indian Gooseberry – is really intended to support joint structure including cartilage, collagen and lubrication. Dyflaminol is an excellent all-purpose supplement to support more immediate benefits. You can combine Arthocin with Dyflaminol, or our premier product, Curamin.

Q: How does the BCM-95® curcumin in Arthocin® compare to other curcumin and turmeric products?

The proper product comparison is curcumin to curcumin. However, since many companies are comparing their curcumin absorption to turmeric, we provide this information as a service to our customers.

    •  Plain curcumin 95% compared to turmeric delivers 20 to 50 times the
        curcumin as the same amount of turmeric.
    •  BCM-95® Curcumin has been proven to deliver 8 to 10 times more
        curcumin into the bloodstream as the same amount of plain curcumin.
    •  Therefore, when compared gram per gram, BCM-95® Curcumin
        delivers 8 to 10 times more curcumin than plain curcumin 95% and
        160 to 500 times more curcumin than that found in an equal
        amount of turmeric.

Did You Know?

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Arthocin®

The boswellia tree is native to India. It grows in very harsh, dry environments. When the bark of the tree is scraped, it secretes a resin called “tears.” These tears are better known as frankincense. Boswellic acid extracted from the tears of the boswellia tree has been used in Ayurvedic medicine for hundreds of years.

ABC Turmeric

Arthocin®

Supports Joint and Back Health, Flexibility, and Comfort*

Product Number: 20196 - 60 Capsules

Dietary Supplement

1 to 2 capsules daily.

Arthocin® is a proprietary formula that effectively promotes joint health and cartilage formation. It safely modulates major signaling and biological pathways of the body that influence joint mobility and health.*

• Supports healthy cartilage structure
• Optimizes comfort and mobility in joints and back
• Clinically tested Devil’s Claw extract increases
   hyaluronic acid synthesis in chondrocytes by up
   to 41%, which can enhance joint lubrication*
• BCM-95® Curcumin absorbed up to 10 times better than
   standard 95% curcumin for more potent biological effects

Combine Arthocin® with Curamin® for an excellent combination and results.

SUPPLEMENT FACTS

Serving Size: 2 Capsules

Servings Per Container: 30 Amount/Serving Daily Value

Proprietary Formula

1,050 mg **

Containing Boswellia (Boswellia serrata) Gum Resin Extract (BosPure®) standardized to contain >70% Total Organic and Boswellic Acids with AKBA >10%, with less than 5% beta-boswellic acids, Curcumin (Curcuma longa) Rhizome Extract (BCM-95®) with curcuminoid complex (curcumin, demethoxycurcumin and bisdemethoxycurcumin), Devil’s Claw (Harpagophytum procumbens) Root Extract standardized to contain >20% harpagosides (by HPLC), Indian Gooseberry (Emblica officinalis) Fruit Extract (25:1) standardized to contain 35% polyphenol content

**Daily Value Not Established

Other Ingredients: vegetable cellulose capsules (hydroxypropyl methylcellulose), cellulose powder, silicon dioxide and vegetable source magnesium stearate

No: sugar, salt, yeast, wheat, gluten, corn, soy, dairy, artificial coloring, artificial flavoring or preservatives.



All ingredients established in human studies for safety and effectiveness.
Does not interfere with stomach, liver or kidney function.

BosPure® and BCM-95® are registered trademarks of Dolcas-Biotech.

If pregnant or nursing, consult a health care practitioner before using.

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The research articles and study abstracts that you are about to view in the EuroPharma USA Library were prepared by independent authors and researchers. They are being reproduced on this site in their entirety. No such article or study abstract is intended to promote a particular manufacturer or brand of dietary supplement. This information is not intended to replace the advice of your health care practitioner. If you have any medical conditions, or are taking any prescription or nonprescription medications, see your physician and discuss all aspects of your treatment before altering or discontinuing any course of therapy. Accordingly, individuals must necessarily assume responsibility for their own actions, safety, and health, and the company is not liable or responsible for any loss, injury, or damage allegedly arising from any information posted on this cite.

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