Evidence
(How it Works)

Cold √™

How it Works:

Cold √™ contains two standardized herbal extracts to help boost the immune system. Andrographis has been an important herb in Ayurvedic medicine since ancient times. Native to southern Asia, it is sometimes called the “King of Bitters” because of its extremely bitter taste. Pelargonium sidoides, commonly known as Umckaloabo or South African Geranium, also has a long history of traditional use in South Africa. The beneficial parts of the plant are the root and rhizome. Each contains very high levels of their key active compounds – andrographolides and umckalin, respectively – to yield a very powerful and potent immune support formula.*

Andrographis (Andrographis paniculata)
Well known for its immune-supporting effects, clinical trials have verified that andrographis can provide significant support for lung and respiratory health. The standardized extract used in Cold √ was shown in a clinical trial to safely support the immune system and increase the body’s natural resistance.*^1-5

Pelargonium (Pelargonium sidoides)
With safety and efficacy for both adults and children established in clinical trials, Pelargonium sidoides has multiple mechanisms of action. It is a potent immunomodulator, stimulating the synthesis and activity of key immune system cells, including macrophages. Pelargonium also has cell-protective effects, and supports respiratory health through stimulation of ciliary activity (beat frequency).* Cilia are the hair-like structures lining the airways.^6-8

References

^{1. Ko HC, Wei BL, Chiou WF. The effect of medicinal plants used in Chinese folk medicine on RANTES secretion by virus-infected human epithelial cells. J Ethnopharmacol. 2006;107(2):205-10.}

^{2. Lin TP, Chen SY, Duh PD, Chang LK, Liu YN. Inhibition of the epstein-barr virus lytic cycle by andrographolide. Biol Pharm Bull. 2008;31(11):2018-23.}

^{3. Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med. 2004;70(4):293-8.}

^{4. Saxena RC. A randomized, double-blind placebo controlled clinical evaluation of standardized extract of Andrographis paniculata (Kalmcold) in patients with uncomplicated upper respiratory tract infection. 2008. Corporate report.}

^{5. Chandrasekaran CV, Thiyagarajan P, Sundarajan K, et al. Evaluation of the genotoxic potential and acute oral toxicity of standardized extract of Andrographis paniculata (KalmCold). Food Chem Toxicol. 2009;47(8):1892-902.}

^{6. Kolodziej H, Kayser O, Radtke OA, Kiderlen AF, Koch E. Pharmacological profile of extracts of Pelargonium sidoides and their constituents. Phytomedicine. 2003;10 Suppl 4:18-24.}

^{7. Kim CE, Griffiths WJ, Taylor PW. Components derived from Pelargonium stimulate macrophage killing of Mycobacterium species. J Appl Microbiol. 2009;106(4):1184-93.}

^{8. Conrad A, Frank U. Extract of Pelargonium sidoides (EPs 7630) displays anti-infective properties by enhanced phagocytosis and differential modulation of host-bacteria interactions. Planta Med. 2008;74(6):682-5.}

Did You Know?

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Cold √™

Plants naturally contain many different phytochemicals (plant chemicals). Standardization refers to the process of identifying a specific compound(s) in a plant, usually the one believed to be primarily responsible for its beneficial health effects, and demonstrating it is present at a certain level through the use of scientifically accepted laboratory testing. This helps ensure a consistently potent extract and consistent results for the user. The two herbal extracts in Cold √ are standardized, andrographis to the key compound andrographolides and Pelargonium sidoides to umckalin.

Cold √™

Supports Healthy Respiratory Tract and Nasal Passages*

Product Number: 12006 - 60 Capsules

Product Number: 12002 - 12 Capsules

Dietary Supplement

2 capsules daily for adults.
1 capsule daily for children 6-12 years.

This beneficial formula combines two clinically researched ingredients that have been shown to support a healthy immune system.

• Supports the body’s natural resistance
• Provides healthy upper respiratory tract support
• Supports a healthy immune system*

Great for adults or children.

SUPPLEMENT FACTS

Serving Size: 2 Capsules

Servings Per Container: 6, 30	Amount/Serving	Daily Value
Proprietary Formula	280 mg	**
Andrographis (Andrographis paniculata) Leaf Extract clinically studied and standardized to contain > 30% andrographolides, Pelargonium (Pelargonium sidoides radix) Root Extract standardized for > 0.3% umckalin ^{** Daily Value not established}

Other Ingredients: rice flour, vegetable cellulose capsules, vegetable source magnesium stearate.

Contains no: sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, or preservatives.

If pregnant or nursing, consult a health care practitioner before using.

Made in the USA

Evidence
(How it Works)

Cold √™

Did You Know?

Cold √™

Cold √™

Dietary Supplement

SUPPLEMENT FACTS

Printable Literature

EUROPHARMA USA LIBRARY DISCLAIMER

Evidence (How it Works)

Cold √™

Did You Know?

Cold √™

Cold √™

Dietary Supplement

SUPPLEMENT FACTS

Printable Literature

EUROPHARMA USA LIBRARY DISCLAIMER

Evidence
(How it Works)