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Evidence
(How it Works)

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Curamin® Extra Strength

How it Works:

A unique combination, this formula combines ingredients with multiple mechanisms of action to support a healthy inflammation response and relieve occasional muscle pain due to exercise and overuse. Curcumin and boswellia modulate COX-2 and 5-LOX. DLPA promotes positive mood and nattokinase increase circulation to move the beneficial compounds to the areas of the body where they are needed.*

DLPA
DL-phenylalanine is an amino acid consisting of equal parts D-phenylalanine and L-phenylalanine. D-phenylalanine inhibits the breakdown of compounds called enkephalins. Enkephalins are associated with positive mood and have been shown to relieve occasional muscle pain due to exercise or overuse.* L-phenylalanine is converted into tyrosine, which in turn is used to produce the brain chemicals norepinephrine and dopamine.1-3

Boswellia (Boswellia serrata)
Clinically tested boswellia (BosPure) helps modulate the activity of 5-LOX (lipoxygenase).* A compound (beta boswellic acid) found in boswellia which interferes with its beneficial activity has been removed, greatly increasing the effectiveness of this extract.4,5

Curcumin (Curcumin longa)
Curcumin, a compound found in the spice turmeric, is associated with many benefits, including: immune system modulation, protection from oxidative stress, and support for a healthy inflammation response.* The specialized extract in this formula has up to 10 times the absorption and blood retention time of standardized 95% curcumin extracts.6-12

Nattokinase
The enzyme nattokinase helps promote blood flow, aiding the other ingredients in the formula to reach all areas of the body.*13, 14

 

 

 

 

 

 

References

1. Ehrenpreis S. Analgesic properties of enkephalinase inhibitors: animal and human studies. Prog Clin Biol Res. 1985;192:363-70.

2. Ehrenpreis S. D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application. Acupunct Electrother Res. 1982;7(2-3):157-72.

3. DLPA. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:189.

4. Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006 Oct;72(12):1100-16.

5. Poeckel D, Tausch L, Altmann A, et al. Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid. Br J Pharmacol. 2005 Oct;146(4):514-24.

6. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun;14(2):141-53.

7. Jacob A, Wu R, Zhou M, Wang P. Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR Res. 2007;89369.

8. Johnson SM, Gulhati P, Arrieta I, et al. Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Res. 2009;29(8):3185-90.

9. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J. 2009;11(3):495-510.

10. Seehofer D, Schirmeier A, Bengmark S, et al. Curcumin Attenuates Oxidative Stress and Inflammatory Response in the Early Phase after Partial Hepatectomy with Simultaneous Intraabdominal Infection in Rats. J Surg Res. 2008 Dec 31.

11. Biswas S, Rahman I. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Mol Nutr Food Res. 2008 ;52(9):987-94.

12. Benny B, Antony B. Bioavailability of Biocurcumax (BCM-95). Spice India. September, 2006:11-15.

13. Hsia CH, Shen MC, Lin JS, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009 ;29(3):190-6.

14. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995 ;18(10):1387-91.

FAQ's

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Curamin® Extra Strength

Q: Does Nattokinase contain Vitamin K?

No. Nattokinase is an isolated and purified enzyme extract from natto (a fermented soybean food), which does contain vitamin K.

Q: Is there a difference between Curamin® and curcumin?

Yes. Curcumin is the beneficial compound found in the root of the turmeric plant. Curamin is the name of the product which contains curcumin along with BosPure® boswellia, DLPA and nattokinase.

Q: Is there a difference between turmeric and curcumin?

Yes. Turmeric is the plant that provides curcumin. A typical turmeric root contains about 2-5% curcumin, so taking an unstandardized, powdered turmeric root product means that very large amounts would be required to get a beneficial amount of curcumin. Additionally, curcumin is poorly absorbed from the gastrointestinal tract. While turmeric is excellent when used as a spice, a bioavailable curcumin extract, such as the BCM-95 used in Curamin, is a better choice for health benefits.

Q: Is it okay to take Curamin® Extra-Strength and Curamin® at the same time?

You can take both of them at the same time, but you may want to start with Curamin Extra-Strength for initial intensive benefits, and then use Curamin as a daily maintenance supplement.

Q: What is the difference between Curamin Extra-Strength and the regular-formula Curamin?

Curamin Extra-Strength simply provides a higher level of ingredients in a different ratio and a more convenient dosage form. Just one or two tablets per day of Curamin Extra-Strength may be enough to provide the benefits people are looking for to support the body’s natural inflammatory response.*

Did You Know?

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Curamin® Extra Strength

The beneficial health effects of the spice turmeric are primarily due to the presence of active compounds known as curcuminoids. The primary curcuminoid is curcumin, and most turmeric extracts are standardized to curcumin content. The other two most active curcuminoids are demethoxycurcumin and bisdemethoxycurcumin. New research is focusing on the benefits for curcuminoids in boosting immune health, aiding in brain function, promoting cellular health, and reducing post-exercise pain and supporting a healthy inflammation response.*

ABC Turmeric

Curamin® Extra Strength

Stop Pain Now*† – Experience Safe and Effective Pain Relief*†

Product Number: 11206 - 60 Tablets

Dietary Supplement

1-2 tablets daily. May take as one tablet three times daily, or as needed. If pregnant or nursing, consult a healthcare practitioner before use.

For Extra Powerful Relief, Curamin® Extra Strength is the Answer!*†

Curamin® Extra Strength provides even more of the effective, clinically-proven ingredients you’ve come to rely on for natural pain relief.*†

• BCM-95® curcumin that absorbs up to 10 times better than standard curcumin extracts.

• BosPure® boswellia is clinically studied for its profound impact on balancing the body’s own natural inflammation response – especially the 5-LOX pathway.*

• DLPA (dl Phenylalanine) helps maximize the effects of endorphins and enkephalins, supporting the body's own response to pain and promoting healthy mood.*†

• Nattokinase helps promote blood flow, aiding the other ingredients in Curamin® Extra Strength to reach all areas of the body.* Plus, it helps balance fibrinogen levels, which can be associated with post-exercise
muscle pain and occasional muscle strain.*

SUPPLEMENT FACTS

Serving Size: 1 Tablet

Servings Per Container: 60 Amount/Serving Daily Value

Proprietary Complex

 902 mg **

DLPA (dl Phenylalanine), Boswellia (Boswellia serrata) Gum Resin Extract (BosPure®) standardized to contain >70% boswellic acids with AKBA >10%, with less than 5% beta-boswellic acids, Curcumin (Curcuma longa) Rhizome Extract (BCM-95®) standardized for curcuminoid complex (curcumin, demethoxycurcumin and bisdemethoxycurcumin), Nattokinase

Other Ingredients: cellulose powder, stearic acid, croscarmellose sodium, silicon dioxide, vegetable source magnesium stearate, glaze.

Contains no: sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, no preservatives. It contains natural ingredients. Color variations are normal.

All ingredients established in human studies for safety and effectiveness. Does not interfere with stomach, liver or kidney function.

† Occasional pain due to exercise or overuse
BosPure® and BCM-95® are registered trademarks of Dolcas-Biotech

If pregnant or nursing, consult a health care practitioner before using.

Made in the USA

Europharma

*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION.
THESE PRODUCTS ARE NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT DISEASE.

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The research articles and study abstracts that you are about to view in the EuroPharma USA Library were prepared by independent authors and researchers. They are being reproduced on this site in their entirety. No such article or study abstract is intended to promote a particular manufacturer or brand of dietary supplement. This information is not intended to replace the advice of your health care practitioner. If you have any medical conditions, or are taking any prescription or nonprescription medications, see your physician and discuss all aspects of your treatment before altering or discontinuing any course of therapy. Accordingly, individuals must necessarily assume responsibility for their own actions, safety, and health, and the company is not liable or responsible for any loss, injury, or damage allegedly arising from any information posted on this cite.

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