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Evidence
(How it Works)

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Curamin® PM

How it Works

A unique combination, this fast-acting formula combines ingredients with multiple mechanisms of action to support the  a healthy inflammation response and relieve occasional muscle pain due to exercise and overuse. Curcumin and boswellia inhibit different inflammatory compounds in the body, and DLPA promotes positive mood.*

DLPA
DL-pheylalanine is an amino acid consisting of equal parts D-phenylalanine and L-phenylalanine. D-phenylalanine inhibits the breakdown of compounds called enkephalins. Enkephalins are associated with positive mood and have been shown to relieve occasional muscle pain due to exercise or overuse.* L-phenylalanine is converted into tyrosine, which in turn is used to produce the brain chemicals norepinephrine and dopamine.1-3

Boswellia (Boswellia serrata)
Clinically tested boswellia (BosPure) helps reduce the activity of the inflammatory enzyme, 5-LOX (lipoxygenase).* A compound (beta boswellic acid) found in boswellia which interferes with its beneficial activity has been removed, greatly increasing the effectiveness of this extract.4,5

Curcumin (Curcumin longa)

Curcumin, a compound found in the spice turmeric, supports multiple pathways in the body and is a potent antioxidant. Some of the benefits associated with curcumin include immune system modulation, protection from oxidative stress, and support for the body’s natural anti-inflammatory response.* The specialized extract in this formula has the highest absorption of any curcumin extract available for maximum health benefits.6-12

Melatonin
Melatonin, naturally available from many sources, is synthesized by the body in the pineal gland. It is generally known for supporting healthy sleep by helping “set” the circadian rhythms – the natural timekeeping and sleep cycle – and is especially important for travelers, shift workers, or anyone with occasional sleeplessness.*13,14

Vitamin B6: Pyridoxal-5-Phosphate (P-5-P)
Vitamin B6 levels are important for mental well-being. Low levels of vitamin B6, especially the active coenzyme form, pyridoxal-5-phosphate found naturally in the blood, may be a factor in serotonin production and other reactions in the body that determine mood and nervous system function.15,16 Interestingly, randomized, double-blind, placebo controlled clinical studies have also shown that vitamin B6 can help relieve stress associated with premenstrual syndrome.17 By supplementing with the pyridoxal-5-phosphate (P-5-P) form, the body doesn’t need to convert the vitamin B6 and can put it to use right away.

References

1. Ehrenpreis S. Analgesic properties of enkephalinase inhibitors: animal and human studies. Prog Clin Biol Res. 1985;192:363-70.

2. Ehrenpreis S. D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application. Acupunct Electrother Res. 1982;7(2-3):157-72.

3. DLPA. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:189.

4. Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006 Oct;72(12):1100-16.

5. Poeckel D, Tausch L, Altmann A, et al. Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid. Br J Pharmacol. 2005 Oct;146(4):514-24.

6. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun;14(2):141-53.

7. Jacob A, Wu R, Zhou M, Wang P. Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR Res. 2007;89369.

8. Johnson SM, Gulhati P, Arrieta I, et al. Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Res. 2009;29(8):3185-90.

9. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J. 2009;11(3):495-510.

10. Seehofer D, Schirmeier A, Bengmark S, et al. Curcumin Attenuates Oxidative Stress and Inflammatory Response in the Early Phase after Partial Hepatectomy with Simultaneous Intraabdominal Infection in Rats. J Surg Res. 2008 Dec 31.

11. Biswas S, Rahman I. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Mol Nutr Food Res. 2008 ;52(9):987-94.

12. Benny B, Antony B. Bioavailability of Biocurcumax (BCM-95). Spice India. September, 2006:11-15.

13. Rios ER, Venâncio ET, Rocha NF, Woods DJ, Vasconcelos S, Macedo D, Sousa FC, Fonteles MM. Melatonin: pharmacological aspects and clinical trends. Int J Neurosci. 2010;120(9):583-90.

14. Pandi-Perumal SR, Srinivasan V, Maestroni GJ, Cardinali DP, Poeggeler B, Hardeland R. Melatonin: Nature's most versatile biological signal? FEBS J. 2006;273(13):2813-38.

15. Bartel PR, Ubbink JB, Delport R, Lotz BP, Becker PJ. Vitamin B-6 supplementation and theophylline-related effects in humans. Am J Clin Nutr. 1994;60(1):93-9.

16. Ebadi M. Regulation and function of pyridoxal phosphate in CNS. Neurochem Int. 1981;3(3-4):181-205.

17. Vitamin B6. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:639.

FAQ's

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Curamin® PM

Q: Can Curamin® PM be habit forming?

No. Curamin® PM only uses non-habit forming natural ingredients that support natural sleep patterns. In fact, as your restful sleep becomes more routine, you’ll probably feel that you need to take Curamin PM only occasionally thereafter.

Q: Why is the BosPure® in Curamin PM screened to reduce beta-boswellic acid?

Because while most boswellic acids are associated with positive benefits, not all of them truly are best when you’re trying to support an active lifestyle. By, and ensuring at least at least 15% or more acetyl-11-keto-β-boswellic acid (AKBA), and screening beta-boswellic acid, to being less than 5%, BosPure is able to provide much greater benefit than most standard boswellic extracts, some of which have up to 15-25% beta-boswellic acid!

Q: Should I take this formula every night or just when needed?

Either would be fine. If supporting healthy sleep and the body’s inflammation response is a concern often, using each night is a great option. However, if it is something you notice only after a busy day of household chores, yard work, or extra activity, Curamin PM is an excellent product for those occasions, too.

Q: Will I feel groggy in the morning after taking this product?

No. Curamin PM is not a sedative, and since it supports healthy sleep cycles, you’ll more than likely feel more refreshed when you wake in the morning.

Did You Know?

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Curamin® PM

Melatonin is a hormone that is found in plants and animals. For humans, melatonin is involved in supporting the circadian rhythms – the natural timing of sleep patterns. In the body, melatonin levels are typically highest at night. But, because so many aspects of modern life can disrupt healthy sleep – television, artificial light, jet travel – there has been an increased interest in supplementing with melatonin to support the natural pattern of healthy sleep.

ABC Turmeric

Curamin® PM

SLEEP YOUR PAIN AWAY*†
Nighttime Relief - Stop Pain Now*†
with Clinically Studied BCM-95®

Product Number: 10330 - 30 Capsules

Dietary Supplement

1 to 2 capsules, preferably 30 minutes before bedtime.

When pain is the problem, Curamin® PM is the answer.*† Enjoy a good night’s sleep with these powerful, effective and clinically proven ingredients. Melatonin and Vitamin B6 (P-5-P) support normal nerve function and sleep. Curamin PM provides natural, restorative sleep without morning grogginess.*

Learn more about Curamin and EuroPharma's complete product line.

SUPPLEMENT FACTS

Serving Size: 2 Capsules

Servings Per Container: 15 Amount/Serving Daily Value

Vitamin B6
(from pyridoxal-5-phosphate)

 60 mg 3000%

Melatonin

 5 mg **

Proprietary Complex

 1400 mg **

DLPA (dl Phenylalanine), Boswellia (Boswellia serrata) Gum Resin Extract (BosPure®) standardized to contain >70% boswellic acids with AKBA >10%, with less than 5% beta-boswellic acids, Curcumin (Curcuma longa) Rhizome Extract (BCM-95®) standardized for curcuminoid complex (curcumin, demethoxycurcumin and bisdemethoxycurcumin)

** Daily Value not established


All ingredients established in human studies for safety and effectiveness. Does not interfere with stomach, liver or kidney function.

Other Ingredients: vegetable cellulose capsules, silicon dioxide, vegetable source magnesium stearate.

Contains no: sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, or preservatives. It contains natural ingredients. Color variations are normal.

†Occasional muscle pain due to exercise and overuse

BosPure® and BCM-95® are registered trademarks of Dolcas-Biotech

If pregnant or nursing, consult a health care practitioner before using.

Made in the USA

Europharma

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