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Evidence
(How it Works)

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Curamin® PM

How it Works

A unique combination, this fast-acting formula combines ingredients with multiple mechanisms of action to support a healthy inflammation response and relieve occasional muscle pain due to exercise and overuse. Curcumin and boswellia support healthy COX-2 and 5-LOX activity, and DLPA promotes positive mood.*

The combination of d,l-pheylalanine is an amino acid consisting of equal parts D-phenylalanine and L-phenylalanine. D-phenylalanine helps maximize the effects of enkephalins. Enkephalins are associated with positive mood and have been shown to relieve occasional muscle pain due to exercise or overuse.* L-phenylalanine is converted into tyrosine, which in turn is used to produce the brain chemicals norepinephrine and dopamine.1-3

The boswellia (Boswellia serrata) in Curamin PM is a clinically-tested extract (BosPure) that supports healthy 5-LOX (lipoxygenase) activity.* A compound (beta boswellic acid) found in boswellia which interferes with its beneficial activity has been reduced, greatly increasing the effectiveness of this extract.4,5

Curcumin (Curcuma longa), a compound found in the spice turmeric, supports multiple pathways in the body and is a potent antioxidant. Some of the benefits associated with curcumin include immune system modulation, protection from oxidative stress, and support for a healthy inflammation response.* The specialized extract in this formula has the highest absorption of any curcumin extract available for maximum health benefits.6-12

Melatonin, naturally available from many sources, is synthesized by the body in the pineal gland. It is generally known for supporting healthy sleep by helping “set” the circadian rhythms – the natural timekeeping and sleep cycle – and is especially important for travelers, shift workers, or anyone with occasional sleeplessness.*13,14

Vitamin B6 as pyridoxal-5-Phosphate (P-5-P) is included in the formula because vitamin B6 levels are important for mental well-being. Low levels of vitamin B6, especially the active coenzyme form, pyridoxal-5-phosphate found naturally in the blood, may be a factor in serotonin production and other reactions in the body that determine mood and nervous system function.15,16

Interestingly, randomized, double-blind, placebo controlled clinical studies have also shown that vitamin B6 can help relieve stress associated with premenstrual syndrome.17 By supplementing with the pyridoxal-5-phosphate (P-5-P) form, the body doesn’t need to convert the vitamin B6 and can put it to use right away.

References

1. Ehrenpreis S. Analgesic properties of enkephalinase inhibitors: animal and human studies. Prog Clin Biol Res. 1985;192:363-70.

2. Ehrenpreis S. D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application. Acupunct Electrother Res. 1982;7(2-3):157-72.

3. DLPA. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:189.

4. Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006 Oct;72(12):1100-16.

5. Poeckel D, Tausch L, Altmann A, et al. Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid. Br J Pharmacol. 2005 Oct;146(4):514-24.

6. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun;14(2):141-53.

7. Jacob A, Wu R, Zhou M, Wang P. Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR Res. 2007;89369.

8. Johnson SM, Gulhati P, Arrieta I, et al. Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Res. 2009;29(8):3185-90.

9. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J. 2009;11(3):495-510.

10. Seehofer D, Schirmeier A, Bengmark S, et al. Curcumin Attenuates Oxidative Stress and Inflammatory Response in the Early Phase after Partial Hepatectomy with Simultaneous Intraabdominal Infection in Rats. J Surg Res. 2008 Dec 31.

11. Biswas S, Rahman I. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Mol Nutr Food Res. 2008 ;52(9):987-94.

12. Benny B, Antony B. Bioavailability of Biocurcumax (BCM-95). Spice India. September, 2006:11-15.

13. Rios ER, Venâncio ET, Rocha NF, Woods DJ, Vasconcelos S, Macedo D, Sousa FC, Fonteles MM. Melatonin: pharmacological aspects and clinical trends. Int J Neurosci. 2010;120(9):583-90.

14. Pandi-Perumal SR, Srinivasan V, Maestroni GJ, Cardinali DP, Poeggeler B, Hardeland R. Melatonin: Nature's most versatile biological signal? FEBS J. 2006;273(13):2813-38.

15. Bartel PR, Ubbink JB, Delport R, Lotz BP, Becker PJ. Vitamin B-6 supplementation and theophylline-related effects in humans. Am J Clin Nutr. 1994;60(1):93-9.

16. Ebadi M. Regulation and function of pyridoxal phosphate in CNS. Neurochem Int. 1981;3(3-4):181-205.

17. Vitamin B6. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:639.

FAQ's

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Curamin® PM

Q: Can Curamin® PM be habit forming?

No. Curamin® PM only uses non-habit forming natural ingredients that support natural sleep patterns. In fact, as your restful sleep becomes more routine, you’ll probably feel that you need to take Curamin PM only occasionally thereafter.

Q: Why is the BosPure® in Curamin PM screened to reduce beta-boswellic acid?

Because while most boswellic acids are associated with positive benefits, not all of them truly are best when you’re trying to support an active lifestyle. By, and ensuring at least at least 15% or more acetyl-11-keto-β-boswellic acid (AKBA), and screening beta-boswellic acid, to being less than 5%, BosPure is able to provide much greater benefit than most standard boswellic extracts, some of which have up to 15-25% beta-boswellic acid!

Q: Should I take this formula every night or just when needed?

Either would be fine. If supporting healthy sleep a healthy inflammation response is a concern often, using each night is a great option. However, if it is something you notice only after a busy day of household chores, yard work, or extra activity, Curamin PM is an excellent product for those occasions, too.

Q: Will I feel groggy in the morning after taking this product?

No. Curamin PM is not a sedative, and since it supports healthy sleep cycles, you’ll more than likely feel more refreshed when you wake in the morning.

Q: How does the BCM-95® curcumin in Curamin® PM compare to other curcumin and turmeric products?

The proper product comparison is curcumin to curcumin. However, since many companies are comparing their curcumin absorption to turmeric, we provide this information as a service to our customers.

    •  Plain curcumin 95% compared to turmeric delivers 20 to 50 times
        the curcumin as the same amount of turmeric.
    •  BCM-95® curcumin has been proven to deliver 8 to 10 times
        more curcumin into the bloodstream as the same amount of
        plain curcumin.
    •  Therefore, when compared gram per gram, BCM-95® curcumin
        delivers 8 to 10 times more curcumin than plain curcumin 95%
        and 160 to 500 times more curcumin than that found in an
        equal amount of turmeric.

Did You Know?

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Curamin® PM

Melatonin is a hormone that is found in plants and animals. For humans, melatonin is involved in supporting the circadian rhythms – the natural timing of sleep patterns. In the body, melatonin levels are typically highest at night. But, because so many aspects of modern life can disrupt healthy sleep – television, artificial light, jet travel – there has been an increased interest in supplementing with melatonin to support the natural pattern of healthy sleep.

ABC Turmeric

Curamin® PM

SLEEP YOUR PAIN AWAY*†
Nighttime Relief - Stop Pain Now*†
with Clinically Studied BCM-95®

Product Number: 10330 - 30 Capsules

Dietary Supplement

1 to 2 capsules,
preferably 30 minutes before bedtime.

When nighttime pain is the problem, Curamin® PM is the answer!*† You can get a good night’s sleep with the powerful, effective ingredients that Curamin® PM provides without morning grogginess.*

Powerful Ingredients for Nighttime Relief
BCM-95® Curcumin is clinically studied and absorbs up to
   10 times better
than standard curcumin extracts.
BosPure® Boswellia is clinically studied and uniquely standardized –
   up to 10 times more powerful than unstandardized boswellia.
DLPA helps maximize the effects of endorphins and enkephalins,
   supporting the body’s own response to pain and promoting
   healthy mood.*
Melatonin helps set your natural timekeeping and sleep cycle –
   and is especially important for travelers, shift workers, or anyone
   with occasional sleepiness.*
Vitamin B6 as Pyridoxal-5-Phosphate (P-5-P) can be used by 
   the body because it is already in the bioactive form. P-5-P is a
   factor in serotonin production and other reactions in the body that
   determine mood and nervous system function.*

Curamin® PM is the smart choice for nighttime relief and
restful sleep.*†

Learn more about Curamin and EuroPharma's complete product line.

SUPPLEMENT FACTS

Serving Size: 2 Capsules

Servings Per Container: 15 Amount/Serving Daily Value

Vitamin B6
(as pyridoxal-5-phosphate)

60 mg 3,000%

Melatonin

5 mg **

Proprietary Complex

1,400 mg **

DLPA (DL-phenylalanine), Boswellia (Boswellia serrata) Gum Resin Extract (BosPure®) standardized to contain >70% Total Organic and Boswellic Acids with AKBA >10%, with less than 5% beta-boswellic acids, Curcumin (Curcuma longa) Rhizome Extract (BCM-95®) enhanced
with turmeric essential oils and standardized for curcuminoid complex (curcumin, demethoxycurcumin and bisdemethoxycurcumin)

** Daily Value not established

Other Ingredients: vegetable cellulose capsules, silicon dioxide, vegetable source magnesium stearate, cellulose powder.

No: sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, or artificial preservatives. It contains natural ingredients. Color variations are normal.

All ingredients established in human studies for safety and effectiveness. Does not interfere with stomach, liver or kidney function.

† Occasional muscle pain due to exercise and overuse
BosPure® and BCM-95® are registered trademarks of Dolcas-Biotech

If pregnant or nursing, consult a health care practitioner before using.

Europharma

EUROPHARMA USA LIBRARY DISCLAIMER

The research articles and study abstracts that you are about to view in the EuroPharma USA Library were prepared by independent authors and researchers. They are being reproduced on this site in their entirety. No such article or study abstract is intended to promote a particular manufacturer or brand of dietary supplement. This information is not intended to replace the advice of your health care practitioner. If you have any medical conditions, or are taking any prescription or nonprescription medications, see your physician and discuss all aspects of your treatment before altering or discontinuing any course of therapy. Accordingly, individuals must necessarily assume responsibility for their own actions, safety, and health, and the company is not liable or responsible for any loss, injury, or damage allegedly arising from any information posted on this cite.

THIS INFORMATION IS BEING PRESENTED PURSUANT TO SECTION 5 OF THE DIETARY SUPPLEMENT HEALTH AND EDUCATION ACT OF 1994-------THE "E" IN DSHEA—BROUGHT TO YOU AS A PUBLIC SERVICE BY EUROPHARMA USA.