Bones and Joints - Pain and Inflammation

Evidence
(How it Works)

Curamin®

A unique combination, this fast-acting formula combines ingredients with multiple mechanisms of action to support the body’s natural anti-inflammatory response and relieve occasional muscle pain due to exercise and overuse. Curcumin and boswellia inhibit different inflammatory compounds in the body. DLPA promotes positive mood and nattokinase increase circulation to move the beneficial compounds to the areas of the body where they are needed.*

DLPA
DL-phenylalanine is an amino acid consisting of equal parts D-phenylalanine and L-phenylalanine. D-phenylalanine inhibits the breakdown of compounds called enkephalins. Enkephalins are associated with positive mood and have been shown to relieve occasional muscle pain due to exercise or overuse.* L-phenylalanine is converted into tyrosine, which in turn is used to produce the brain chemicals norepinephrine and dopamine.^1-3

Boswellia (Boswellia serrata)
Clinically tested boswellia (BosPure) helps reduce the activity of the inflammatory enzyme, 5-LOX (lipoxygenase).* A compound (beta boswellic acid) found in boswellia which interferes with its beneficial activity has been removed, greatly increasing the effectiveness of this extract.^4,5

Curcumin (Curcumin longa)
Curcumin, a compound found in the spice turmeric, inhibits multiple inflammation pathways in the body. It is also a potent antioxidant. Some of the benefits associated with curcumin include immune system modulation, protection from oxidative stress, and support for the body’s natural anti-inflammatory response.* The specialized extract in this formula has the highest absorption of any curcumin extract available for maximum health benefits.^6-12

Nattokinase
The enzyme nattokinase helps promote blood flow, aiding the other ingredients in the formula to reach all areas of the body.*^12,13

References

1. Ehrenpreis S. Analgesic properties of enkephalinase inhibitors: animal and human studies. Prog Clin Biol Res. 1985;192:363-70.

2. Ehrenpreis S. D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application. Acupunct Electrother Res. 1982;7(2-3):157-72.

3. DLPA. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:189.

4. Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006 Oct;72(12):1100-16.

5. Poeckel D, Tausch L, Altmann A, et al. Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid. Br J Pharmacol. 2005 Oct;146(4):514-24.

6. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun;14(2):141-53.

7. Jacob A, Wu R, Zhou M, Wang P. Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR Res. 2007;89369.

8. Johnson SM, Gulhati P, Arrieta I, et al. Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Res. 2009;29(8):3185-90.

9. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J. 2009;11(3):495-510.

10. Seehofer D, Schirmeier A, Bengmark S, et al. Curcumin Attenuates Oxidative Stress and Inflammatory Response in the Early Phase after Partial Hepatectomy with Simultaneous Intraabdominal Infection in Rats. J Surg Res. 2008 Dec 31.

11. Biswas S, Rahman I. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Mol Nutr Food Res. 2008 ;52(9):987-94.

12. Benny B, Antony B. Bioavailability of Biocurcumax (BCM-95). Spice India. September, 2006:11-15.

13. Hsia CH, Shen MC, Lin JS, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009 ;29(3):190-6.

14. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995 ;18(10):1387-91.

Additional Health Information

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Curamin®

Testimonials

Curamin®

Stop Pain Now – Experience Relief Like Never Before*†
Fast, Safe and Effective

Product Number: 10260 - 60 Capsules

Product Number: 10220 - 120 Capsules

Dietary Supplement

1 capsule three times daily, or as needed.

The synergistic blend in Curamin® is 20X more powerful than just using curcumin 95%. Now, you can experience relief with Curamin. Curamin is a unique and proprietary formula that enhances the body’s natural defense mechanism for the relief of occasional pain.*† Guaranteed Satisfaction.

Visit www.Curamin.com to read what others have experienced.

SUPPLEMENT FACTS

Serving Size: 3 Capsules

Servings Per Container: 20 or 40	Amount/Serving	Daily Value
Proprietary EP612 Complex	1,454 mg	**
DLPA (dl Phenylalanine), Boswellia (Boswellia serrata) Extract (BosPure®) standardized to contain >70% boswellic acids with 10-15% AKBA, Curcumin (Curcuma longa) Extract (BCM-95®) standardized for curcuminoid complex (curcumin, demethoxycurcumin and bisdemethoxycurcumin), Nattokinase. ^{**Daily Value Not Established}

Other Ingredients: vegetable cellulose capsule, silicon dioxide and vegetable source magnesium stearate.

Contains no: sugar, salt, soy, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring or preservatives. It contains only natural ingredients. Color variations are normal.

^{Lab tested for purity and safety.
BosPure® and BCM-95® are registered trademarks of Dolcas-Biotech.

† Occasional muscle pain due to exercise and overuse}

If pregnant or nursing, consult a health care practitioner before using.

Made in the USA

Did You Know?

The beneficial health effects of the spice turmeric are primarily due to the presence of active compounds known as curcuminoids. The primary curcuminoid is curcumin, and most turmeric extracts are standardized to curcumin content. The other two most active curcuminoids are demethoxycurcumin and bisdemethoxycurcumin. New research is focusing on the benefits for curcuminoids in boosting immune health, aiding in brain function, promoting cellular health, and reducing post-exercise pain and inflammation.*

*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION.
THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT DISEASE.

EUROPHARMA USA LIBRARY DISCLAIMER

The research articles and study abstracts that you are about to view in the EuroPharma USA Library were prepared by independent authors and researchers. They are being reproduced on this site in their entirety. No such article or study abstract is intended to promote a particular manufacturer or brand of dietary supplement. This information is not intended to replace the advice of your health care practitioner. If you have any medical conditions, or are taking any prescription or nonprescription medications, see your physician and discuss all aspects of your treatment before altering or discontinuing any course of therapy. Accordingly, individuals must necessarily assume responsibility for their own actions, safety, and health, and the company is not liable or responsible for any loss, injury, or damage allegedly arising from any information posted on this cite.

THIS INFORMATION IS BEING PRESENTED PURSUANT TO SECTION 5 OF THE DIETARY SUPPLEMENT HEALTH AND EDUCATION ACT OF 1994-------THE “E” IN DSHEA—BROUGHT TO YOU AS A PUBLIC SERVICE BY EUROPHARMA USA.

Evidence (How it Works)

Curamin®

Additional Health Information

Curamin®

Testimonials

Curamin®

Dietary Supplement

SUPPLEMENT FACTS

Did You Know?

Articles

Media

Studies

EUROPHARMA USA LIBRARY DISCLAIMER

Evidence
(How it Works)