Evidence
(How it Works)

Curamin®

How it Works:

A unique combination, this formula combines ingredients with multiple mechanisms of action to support a healthy inflammation response and relieve occasional muscle pain due to exercise and overuse. Curcumin and boswellia modulate COX-2 and 5-LOX. DLPA promotes positive mood and nattokinase increase circulation to move the beneficial compounds to the areas of the body where they are needed.*

DLPA
DL-phenylalanine is an amino acid consisting of equal parts D-phenylalanine and L-phenylalanine. D-phenylalanine inhibits the breakdown of compounds called enkephalins. Enkephalins are associated with positive mood and have been shown to relieve occasional muscle pain due to exercise or overuse.* L-phenylalanine is converted into tyrosine, which in turn is used to produce the brain chemicals norepinephrine and dopamine.^1-3

Boswellia (Boswellia serrata)
Clinically tested boswellia (BosPure) helps modulate the activity of 5-LOX (lipoxygenase).* A compound (beta boswellic acid) found in boswellia which interferes with its beneficial activity has been removed, greatly increasing the effectiveness of this extract.^4,5

Curcumin (Curcumin longa)
Curcumin, a compound found in the spice turmeric, is associated with many benefits, including: immune system modulation, protection from oxidative stress, and support for a healthy inflammation response.* The specialized extract in this formula has up to 10 times the absorption and blood retention time of standardized 95% curcumin extracts.^6-12

Nattokinase
The enzyme nattokinase helps promote blood flow, aiding the other ingredients in the formula to reach all areas of the body.*^{13, 14}

References

^{1. Ehrenpreis S. Analgesic properties of enkephalinase inhibitors: animal and human studies. Prog Clin Biol Res. 1985;192:363-70.}

^{2. Ehrenpreis S. D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application. Acupunct Electrother Res. 1982;7(2-3):157-72.}

^{3. DLPA. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:189.}

^{4. Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006 Oct;72(12):1100-16.}

^{5. Poeckel D, Tausch L, Altmann A, et al. Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid. Br J Pharmacol. 2005 Oct;146(4):514-24.}

^{6. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun;14(2):141-53.}

^{7. Jacob A, Wu R, Zhou M, Wang P. Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR Res. 2007;89369.}

^{8. Johnson SM, Gulhati P, Arrieta I, et al. Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Res. 2009;29(8):3185-90.}

^{9. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J. 2009;11(3):495-510.}

^{10. Seehofer D, Schirmeier A, Bengmark S, et al. Curcumin Attenuates Oxidative Stress and Inflammatory Response in the Early Phase after Partial Hepatectomy with Simultaneous Intraabdominal Infection in Rats. J Surg Res. 2008 Dec 31.}

^{11. Biswas S, Rahman I. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Mol Nutr Food Res. 2008 ;52(9):987-94.}

^{12. Benny B, Antony B. Bioavailability of Biocurcumax (BCM-95). Spice India. September, 2006:11-15.}

^{13. Hsia CH, Shen MC, Lin JS, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009 ;29(3):190-6.}

^{14. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995 ;18(10):1387-91.}

FAQ's

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Curamin®

Q: Does Nattokinase contain Vitamin K?

No. Nattokinase is an isolated and purified enzyme extract from natto (a fermented soybean food), which does contain vitamin K.

Q: Why do some capsules occasionally appear lighter/darker yellow than others?

It’s not unusual for natural ingredients to have some variance in color. The important thing is that the standardized compounds within the herbal ingredients are the same. When you see variations, just keep in mind that it is simply the result of being a botanical product.

Q: Is there a difference between Curamin® and curcumin?

Yes. Curcumin is the beneficial compound found in the root of the turmeric plant. Curamin is the name of the product which contains curcumin along with BosPure® boswellia, DLPA and nattokinase.

Q: Is there a difference between turmeric and curcumin?

Yes. Turmeric is the plant that provides curcumin. A typical turmeric root contains about 2-5% curcumin, so taking an unstandardized, powdered turmeric root product means that very large amounts would be required to get a beneficial amount of curcumin. Additionally, curcumin is poorly absorbed from the gastrointestinal tract. While turmeric is excellent when used as a spice, a bioavailable curcumin extract, such as the BCM-95 used in Curamin, is a better choice for health benefits.

Q: My mother can’t swallow capsules. Can she open them up and take them with food?

Yes, opening the capsules and mixing with a food or drink is an excellent way for anyone who can’t swallow capsules to use Curamin®.

Q: Why would you put silicon dioxide in your wonderful product?

Silicon dioxide is just there to make sure that the premium ingredients in Curamin® are properly mixed and measured so that every capsule guarantees the same effective, beneficial components. Many botanical ingredients are, by their nature, “sticky” and can tend to clump if they are not mixed with a minute amount of inert, harmless natural material.

Did You Know?

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Curamin®

The beneficial health effects of the spice turmeric are primarily due to the presence of active compounds known as curcuminoids. The primary curcuminoid is curcumin, and most turmeric extracts are standardized to curcumin content. The other two most active curcuminoids are demethoxycurcumin and bisdemethoxycurcumin. New research is focusing on the benefits for curcuminoids in boosting immune health, aiding in brain function, promoting cellular health, and reducing post-exercise pain and supporting a healthy inflammation response.*

Testimonials

Curamin®

Stop Pain Now*† – Experience Safe and Effective Pain Relief*†

Product Number: 10210 - 21 Capsules - Travel Size

Product Number: 10260 - 60 Capsules

Product Number: 10220 - 120 Capsules

Product Number: 10270 - 120 g Powder

Dietary Supplement

Take three capsules daily, or as needed. May take as one capsule three times daily.

Got Pain? Get Curamin^®
Safe and Effective Pain Relief^*†

Most effective curcumin available
Features clinically proven BCM-95® bioavailable curcumin
Ingredient efficacy confirmed in published human studies

The Secret of Curamin's Power

What's the secret? Combining the best of the best. Curamin contains a super-absorption curcumin called BCM-95 that can be up to 10 times stronger than plain curcumin products.

Known for its ability to balance the body's natural inflammatory response, BCM-95® has been proven in published clinical studies to provide consistent and long-lasting effects. The impact of BosPure® boswellia is enhanced by removal of pro-inflammatory compounds commonly found in this plant. And DLPA (DL-phenylalanine) has been shown to help maximize the effects of endorphins and enkephalins, the body's own powerful pain relievers. Rounding out the formula is an enzyme, nattokinase, that not only boosts healthy circulation, it has a direct impact on muscle pain via its ability to balance fibrinogen levels in the body.*

2012 Essentials Award Winner – Top Supplements of 2012 – Taste For Life Magazine
________________________________________________

2011 Vity Awards Winner - Vitamin Retailer Magazine
CURAMIN® WINS in 3 Different Categories:
Specialty and Herbal Supplement Category - Best Herbal Supplement
Specialty and Herbal Supplement Category - Best New Herbal Supplement
Natural Medicine Category - Best New Natural Remedy
________________________________________________

Best of Supplements Awards Winner 2011 - Better Nutrition

4 Years Running - Pain and Inflammation Category

________________________________________________

2011 Natural Choice Award, Best Specialty Supplement - WholeFoods

When pain is the problem, Curamin® is the answer.*† Blending four powerful, effective and clinically proven ingredients into one award-winning product provides natural pain relief.*†

UNCONDITIONALLY GUARANTEED

Learn more about Curamin and EuroPharma's complete product line.

SUPPLEMENT FACTS

Serving Size: 3 Capsules

Servings Per Container: 7, 20 or 40	Amount/Serving	Daily Value
Proprietary Complex	2,181 mg	**
DLPA (dl Phenylalanine), Boswellia (Boswellia serrata) Gum Resin Extract (BosPure®) standardized to contain >70% boswellic acids with AKBA >10%, with less than 5% beta-boswellic acids, Curcumin (Curcuma longa) Rhizome Extract (BCM-95®) standardized for curcuminoid complex (curcumin, demethoxycurcumin and bisdemethoxycurcumin), Nattokinase ^{**Daily Value Not Established}

Other Ingredients: vegetable cellulose capsule, silicon dioxide and vegetable source magnesium stearate. Contains Soy (less than 5 parts per million)

Contains no: sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring or preservatives. It contains only natural ingredients. Color variations are normal.

VEGAN

All ingredients established in human studies for safety and effectiveness. Does not interfere with stomach, liver or kidney function.

†Occasional muscle pain due to exercise and overuse

Contains Soy (non-GMO, less than 5 parts per million)††

††All EuroPharma products are actually free of soy. We list “contains soy” if a formula contains phospholipids, nattokinase and vitamin K2 which are extracted from soy. The chance of these healthy ingredients causing a risk of allergies is extremely low or non-existent. They contain a possible soy content in parts per million. However, for the safety and comfort of our customers, we provide soy information.

^{Lab tested for purity and safety.
BosPure® and BCM-95® are registered trademarks of Dolcas-Biotech.}

If pregnant or nursing, consult a health care practitioner before using.

Made in the USA

Evidence
(How it Works)

Curamin®

FAQ's

Curamin®

Did You Know?

Curamin®

Testimonials

Curamin®

Dietary Supplement

Got Pain? Get Curamin^®
Safe and Effective Pain Relief^*†

SUPPLEMENT FACTS

Printable Literature

Articles

Press Releases

Studies

EUROPHARMA USA LIBRARY DISCLAIMER

Evidence (How it Works)

Curamin®

FAQ's

Curamin®

Did You Know?

Curamin®

Testimonials

Curamin®

Dietary Supplement

Got Pain? Get Curamin®Safe and Effective Pain Relief*†

SUPPLEMENT FACTS

Printable Literature

Articles

Press Releases

Studies

EUROPHARMA USA LIBRARY DISCLAIMER

Evidence
(How it Works)

Got Pain? Get Curamin^®
Safe and Effective Pain Relief^*†