Evidence
(How it Works)

Dyflaminol™

How it Works:

Dyflaminol™ combines three herbal extract – ginger, curcumin and boswellia – known for their ability to support a healthy inflammation repsonse with DLPA, an amino acid which acts in a unique way to promote mood.*

DLPA
DL-phenylalanine is an amino acid consisting of equal parts D-phenylalanine and L-phenylalanine. D-phenylalanine inhibits the breakdown of compounds called enkephalins. Enkephalins are associated with positive mood and have been shown to relieve occasional muscle pain due to exercise or overuse.* L-phenylalanine is converted into tyrosine, which in turn is used to produce the brain chemicals norepinephrine and dopamine.^1-3

Boswellia (Boswellia serrata)
Clinically tested boswellia (BosPure) helps modulate the activity of the enzyme 5-LOX (lipoxygenase).* A compound (beta boswellic acid) found in boswellia which interferes with its beneficial activity has been removed, greatly increasing the effectiveness of this extract.^4-5

Curcumin (Curcuma longa)
Curcumin, a compound found in the spice turmeric, supports multiple pathways in the body and is a potent antioxidant. Some of these benefits include; immune system modulation, protection from oxidative stress, and support for a healthy inflammation response.* The specialized extract in this formula has up to 10 times the absorption of standard curcumin extracts.^6-12

Ginger (Zingiber officinale)
Ginger contains beneficial compounds called gingerols. Research has shown that one mechanism of action is to modulate the both the LOX (lipoxygenase) and the COX (cyclooxygenase) pathways.*^13,14

References

^{1. Ehrenpreis S. Analgesic properties of enkephalinase inhibitors: animal and human studies. Prog Clin Biol Res. 1985;192:363-70.}

^{2. Ehrenpreis S. D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application. Acupunct Electrother Res. 1982;7(2-3):157-72.}

^{3. DLPA. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:189.}

^{4. Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006;72(12):1100-16.}

^{5. Poeckel D, Tausch L, Altmann A, et al. Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid. Br J Pharmacol. 2005;146(4):514-24.}

^{6. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14(2):141-53.}

^{7. Jacob A, Wu R, Zhou M, Wang P. Mechanism of the anti-inflammatory effect of curcumin: PPAR-gamma activation. PPAR Res. 2007;2007:89369.}

^{8. Johnson SM, Gulhati P, Arrieta I, et al. Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Res. 2009;29(8):3185-90.}

^{9. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J. 2009;11(3):495-510.}

^{10. Seehofer D, Schirmeier A, Bengmark S, et al. Curcumin attenuates oxidative stress and inflammatory response in the early phase after partial hepatectomy with simultaneous intraabdominal infection in rats. J Surg Res. 2008 Dec 31.}

^{11. Biswas S, Rahman I. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Mol Nutr Food Res. 2008;52(9):987-94.}

^{12. Benny B, Antony B. Bioavailability of Biocurcumax (BCM-95). Spice India. September, 2006:11-15.}

^{13. Zingiber officinale (ginger). Monograph. Altern Med Rev. 2003;8(3):331-5.}

^{14. Srivastava KC, Mustafa T. Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Med Hypotheses. 1992 Dec;39(4):342-8.}

Did You Know?

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Dyflaminol™

Ginger has been used in Indian and Chinese traditional medicine for thousands of years. The botanical name for Ginger - Zingiber officinale - comes from the Sanskrit word singabera, which means 'shaped like a horn' (referring to the antler-like rhizome, or underground stem). In the 1800s bartenders in England kept shakers of powdered ginger spice available for their customers to sprinkle into their drinks. Tradition has it that this practice was the origin of ginger ale.

Dyflaminol™

Healthy Inflammation Response*

Product Number: 20126 - 60 Capsules

Product Number: 20122 - 120 Capsules

Dietary Supplement

3 capsules daily; may be taken as 1 capsule 3 times a day, or as directed by your health care practitioner. Use as needed.

Dyflaminol™ combines BCM-95® bioavailable curcumin with two potent, standardized herbal extracts – ginger and boswellia – also known for their ability to support a healthy inflammation response. The amino acid DLPA acts in a unique way to promote mood. Together, these ingredients provide unprecedented levels of support throughout the body.*

SUPPLEMENT FACTS

Serving Size: 3 Capsules

Servings Per Container: 20 or 40	Amount/Serving	Daily Value
Proprietary Complex	2,115 mg	**
DLPA (dl Phenylalanine), Boswellia (Boswellia serrata) Extract (BosPure®) standardized to contain >70% boswellic acid with AKBA >15%, with less than 5% beta-boswellic acids, Curcumin (Curcuma longa) Extract (BCM-95®) standardized for curcuminoid complex (curcumin, demethoxycurcumin and bisdemethoxycurcumin), Ginger (Zingiber officinale) Extract standardized to contain 5% gingerols^{**Daily Value Not Established.} All ingredients established in human studies for safety and effectiveness. Does not interfere with stomach, liver or kidney function.

Servings Per Container: 20 or 40

Amount/Serving

Daily Value

Proprietary Complex

2,115 mg

DLPA (dl Phenylalanine), Boswellia (Boswellia serrata) Extract (BosPure®) standardized to contain >70% boswellic acid with AKBA >15%, with less than 5% beta-boswellic acids, Curcumin (Curcuma longa) Extract (BCM-95®) standardized for curcuminoid complex (curcumin, demethoxycurcumin and bisdemethoxycurcumin), Ginger (Zingiber officinale) Extract standardized to contain 5% gingerols^{**Daily Value Not Established.}

All ingredients established in human studies for safety and effectiveness. Does not interfere with stomach, liver or kidney function.

Other Ingredients: vegetable cellulose capsules, cellulose powder, silicon dioxide and vegetable source magnesium stearate

Contains no: sugar, salt, soy, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring or preservatives. Color variations are normal.

^{BosPure® and BCM-95® are registered trademarks of Dolcas-Biotech.}

If pregnant or nursing, consult a health care practitioner before using.

Made in the USA

Evidence
(How it Works)

Dyflaminol™

Did You Know?

Dyflaminol™

Dyflaminol™

Dietary Supplement

SUPPLEMENT FACTS

Printable Literature

Articles

Press Releases

Studies

EUROPHARMA USA LIBRARY DISCLAIMER

Evidence (How it Works)

Dyflaminol™

Did You Know?

Dyflaminol™

Dyflaminol™

Dietary Supplement

SUPPLEMENT FACTS

Printable Literature

Articles

Press Releases

Studies

EUROPHARMA USA LIBRARY DISCLAIMER

Evidence
(How it Works)