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Evidence
(How it Works)

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Dyflaminol™

How it Works:

Dyflaminol™ combines three herbal extract – ginger, curcumin and boswellia – known for their ability to support a healthy inflammation repsonse with d,l-phenlylalanine (DLPA), an amino acid which acts in a unique way to promote mood.*

d,l-phenylalanine (DLPA) 
The amino acid d,l-phenylalanine consists of equal parts D-phenylalanine and L-phenylalanine. D-phenylalanine helps maximize the effects of enkephalins. Enkephalins are associated with positive mood and have been shown to relieve occasional muscle pain due to exercise or overuse.* L-phenylalanine is converted into tyrosine, which in turn is used to produce the brain chemicals norepinephrine and dopamine.1-3

Boswellia (Boswellia serrata)
Clinically tested boswellia (BosPure) supports healthy 5-LOX (lipoxygenase) activity.* A compound (beta boswellic acid) found in boswellia which interferes with its beneficial activity has been removed, greatly increasing the effectiveness of this extract.4-5

Curcumin (Curcuma longa)
Curcumin, a compound found in the spice turmeric, supports multiple pathways in the body and is a potent antioxidant. Some of these benefits include; immune system modulation, protection from oxidative stress, and support for a healthy inflammation response.* The specialized extract in this formula has up to 10 times the absorption of standard curcumin extracts.6-12

Ginger (Zingiber officinale)
Ginger contains beneficial compounds called gingerols. Research has shown that one mechanism of action is to support both the LOX (lipoxygenase) and the COX (cyclooxygenase) pathways.*13,14

References

1. Ehrenpreis S. Analgesic properties of enkephalinase inhibitors: animal and human studies. Prog Clin Biol Res. 1985;192:363-70.

2. Ehrenpreis S. D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application. Acupunct Electrother Res. 1982;7(2-3):157-72.

3. DLPA. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:189.

4. Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006;72(12):1100-16.

5. Poeckel D, Tausch L, Altmann A, et al. Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid. Br J Pharmacol. 2005;146(4):514-24.

6. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14(2):141-53.

7. Jacob A, Wu R, Zhou M, Wang P. Mechanism of the anti-inflammatory effect of curcumin: PPAR-gamma activation. PPAR Res. 2007;2007:89369.

8. Johnson SM, Gulhati P, Arrieta I, et al. Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Res. 2009;29(8):3185-90.

9. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J. 2009;11(3):495-510.

10. Seehofer D, Schirmeier A, Bengmark S, et al. Curcumin attenuates oxidative stress and inflammatory response in the early phase after partial hepatectomy with simultaneous intraabdominal infection in rats. J Surg Res. 2008 Dec 31.

11. Biswas S, Rahman I. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Mol Nutr Food Res. 2008;52(9):987-94.

12. Benny B, Antony B. Bioavailability of Biocurcumax (BCM-95). Spice India. September, 2006:11-15.

13. Zingiber officinale (ginger). Monograph. Altern Med Rev. 2003;8(3):331-5.

14. Srivastava KC, Mustafa T. Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Med Hypotheses. 1992 Dec;39(4):342-8.

FAQ's

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Dyflaminol™

Q: Why is the BosPure® in Dyflaminol screened to reduce beta-boswellic acid?

While most boswellic acids are associated with positive benefits, beta-boswellic acid is pro-inflammatory. Keeping it to less than 5% greatly enhances the effectiveness of BosPure® Boswellia.

Q: What is the difference between Dyflaminol and Arthocin?

Dyflaminol is an excellent all-purpose supplement to support more immediate benefits. The combination and level of ingredients in Arthocin – especially given its high levels of Devil’s Claw and Indian Gooseberry – is intended to support joint structure and lubrication.

Q: How does the BCM-95® curcumin in Dyflaminol compare to other curcumin and turmeric products?

The proper product comparison is curcumin to curcumin. However, since many companies are comparing their curcumin absorption to turmeric, we provide this information as a service to our customers.

    •  Plain curcumin 95% compared to turmeric delivers 20 to 50 times
        the curcumin as the same amount of turmeric.
    •  BCM-95® Curcumin has been proven to deliver 8 to 10 times
        more curcumin into the bloodstream as the same amount of
        plain curcumin.
    •  Therefore, when compared gram per gram, BCM-95® Curcumin
        delivers 8 to 10 times more curcumin than plain curcumin 95%
        and 160 to 500 times more curcumin than that found in an
        equal amount of turmeric.

Q: Can Dyflaminol and Curamin® be taken together? What would be the benefits?

Dyflaminol and Curamin can be used together, though many consumers choose to use one or the other due to the great similarity of ingredients.

Did You Know?

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Dyflaminol™

Ginger has been used in Indian and Chinese traditional medicine for thousands of years. The botanical name for Ginger - Zingiber officinale - comes from the Sanskrit word singabera, which means 'shaped like a horn' (referring to the antler-like rhizome, or underground stem). In the 1800s bartenders in England kept shakers of powdered ginger spice available for their customers to sprinkle into their drinks. Tradition has it that this practice was the origin of ginger ale.

ABC Turmeric

Dyflaminol™

Product Number: 20126 - 60 Capsules

Dietary Supplement

Three capsules daily. May take as one capsule three times daily.

Dyflaminol™ combines BCM-95® high absorption curcumin with two potent, standardized herbal extracts – BosPure® Boswellia and ginger – to provide optimal support for a healthy inflammation response throughout the body. DLPA enhances brain endorphin activity, which plays an important role in pain relief.*†

SUPPLEMENT FACTS

Serving Size: 3 Capsules

Servings Per Container: 20 Amount/Serving Daily Value

Proprietary Complex

2,115 mg **

DLPA (DL-phenylalanine), Boswellia (Boswellia serrata) Gum Resin Extract (BosPure®) standardized to contain >70% Total Organic and Boswellic Acids with AKBA >10%, with less than 5% betaboswellic acids, Curcumin (Curcuma longa) Rhizome Extract (BCM-95®) standardized for curcuminoid complex (curcumin, demethoxycurcumin and bisdemethoxycurcumin), Ginger (Zingiber officinale) Root Extract standardized to contain 5% gingerols

**Daily Value Not Established

Other Ingredients: hydroxypropyl methylcellulose (vegetable cellulose capsules), silicon dioxide, vegetable source magnesium stearate, cellulose powder.

No: sugar, salt, soy, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring or preservatives. Color variations are normal.

BosPure® and BCM-95® are registered trademarks of Dolcas-Biotech.

† Occasional pain due to exercise or overuse

If pregnant or nursing, consult a health care practitioner before using.

Made in the USA

Europharma
BCM-95 & Curcumin Video Image

View this short video about BCM-95 & Curcumin

Length: 10:51

EUROPHARMA USA LIBRARY DISCLAIMER

The research articles and study abstracts that you are about to view in the EuroPharma USA Library were prepared by independent authors and researchers. They are being reproduced on this site in their entirety. No such article or study abstract is intended to promote a particular manufacturer or brand of dietary supplement. This information is not intended to replace the advice of your health care practitioner. If you have any medical conditions, or are taking any prescription or nonprescription medications, see your physician and discuss all aspects of your treatment before altering or discontinuing any course of therapy. Accordingly, individuals must necessarily assume responsibility for their own actions, safety, and health, and the company is not liable or responsible for any loss, injury, or damage allegedly arising from any information posted on this cite.

THIS INFORMATION IS BEING PRESENTED PURSUANT TO SECTION 5 OF THE DIETARY SUPPLEMENT HEALTH AND EDUCATION ACT OF 1994-------THE "E" IN DSHEA—BROUGHT TO YOU AS A PUBLIC SERVICE BY EUROPHARMA USA.