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Evidence
(How it Works)

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Healthy Feet & Nerves™

How It Works:

Growing research and evidence points to the use of supplemental vitamins, minerals, and other nutrients to support healthy nerve function, blood sugar metabolism, and inflammatory response.* The ingredients in Healthy Feet and Nerves have been carefully selected for anyone who has concerns with healthy glucose metabolism and nerve function throughout the body, but especially in the feet.*1

B-vitamins: Thiamin (vitamin B1) and Riboflavin (vitamin B2) are also critical nutrients for anyone with nerve health concerns. The active form of vitamin B6, known as pyridoxal-5-phosphate (P-5-P), vitamin B12 (methylcobalamin), and folic acid (methylfolate) do not require conversion by the liver, and can go to work right away.* B-vitamins are known for their support of healthy blood sugar levels already within normal limits, carbohydrate metabolism (assisting our body in turning food into energy) and healthy nerve system structure and response.*1-7

Niacin: Niacin supports healthy triglyceride and LDL cholesterol balance, which is a key factor for anyone with concerns about blood sugar levels and blood vessel  health.*8

Pantothenic Acid:

Pantothenic Acid is a B-vitamin and sometimes referred to as “vitamin B5”. Deficiencies of pantothenic acid can cause numbness and tingling in the feet. In the body, pantothenic acid is primary active as Coenzyme A and as acyl carrier protein, and is involved in many important functions throughout the body, including healthy tissue formation. However, the levels of Coenzyme A can be affected in the body by a number of hormones, including insulin.*9,10

Alpha-lipoic acid: Alpha-lipoic acid has been shown to boost levels of glutathione, one of the body’s natural free-radical fighters, which keeps nerve tissue healthy and functioning properly. Clinical studies have shown that use of supplemental alpha-lipoic acid can support healthy blood sugar levels and nerve health.*11,12

Essential trace minerals, chromium and zinc: Chromium in the form of chromium nicotinate has been shown to be effective at promoting a healthy insulin response.*13-16 Zinc is especially important for healthy tissue formation and maintenance.*17

The chromium nicotinate and zinc provided in Healthy Feet and Nerves is a chelated mineral using The Real Amino Acid Chelate System (TRAACS®), so they can be readily and completely absorbed and used by the body.*

BosPure® boswellia: Inflammation is one of the biggest challenges for individuals with concerns regarding nerve health and their feet. Boswellic acids – found in boswellia, have been shown to support a healthy inflammation response. However, not all boswellia extracts are the same. Healthy Feet and Nerves provides BosPure® boswellia, which is screened in a manner that reduces beta-boswellic acid content to less than 5%, and assures that at least 15% or more of the extract includes acetyl-11-keto-β-boswellic acid (AKBA)  – that greatly increases its benefit. 18-20 BosPure has up to a 2-fold greater impact on natural inflammatory factors compared to standard boswellia extracts.*18,19

References

  1. Farvid MS, Homayouni F, Amiri Z, Adelmanesh F. Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation. Diabetes Res Clin Pract. 2011 Apr 13.
  2. Hou CT, Wu YH, Huang PN, Cheng CH, Huang YC. Higher plasma pyridoxal 5'-phosphate is associated with better blood glucose responses in critically ill surgical patients with inadequate vitamin B-6 status. Clin Nutr. 2011 Feb 22. [Epub ahead of print]
  3. Vitamin B6. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:639.
  4. Vitamin B12. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008: 644-652.
  5. Folate. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008: 225-234.
  6. Coombs GF. The Vitamins: Fundamental Aspects in Nutrition and Health. Academic Press, Inc. New York, NY; 1992.
  7. Page GL, Laight D, Cummings MH. Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease. Int J Clin Pract. 2011 Jun;65(6):684-90. doi: 10.1111/j.1742-1241.2011.02680.x.
  8. Tavintharan S, Woon K, Pek LT, Jauhar N, Dong X, Lim SC, Sum CF. Niacin results in reduced monocyte adhesion in patients with type 2 diabetes mellitus. Atherosclerosis. 2011 Mar;215(1):176-9.
  9. Tahiliani AG, Beinlich CJ. Pantothenic acid in health and disease. Vitam Horm. 1991;46:165-228.
  10. Pantothenic Acid. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:479-483.
  11. Vallianou N, Evangelopoulos A, Koutalas P. Alpha-lipoic Acid and diabetic neuropathy. Rev Diabet Stud. 2009 Winter;6(4):230-6.
  12. Kishi Y, Schmelzer JD, Yao JK, Zollman PJ, Nickander KK, Tritschler HJ, Low PA. Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy. Diabetes.1999 Oct;48(10):2045-51.
  13. Chromium. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:143.
  14. Lau FC, Bagchi M, Sen CK, Bagchi D. Nutrigenomic basis of beneficial effects of chromium(III) on obesity and diabetes. Mol Cell Biochem. 2008;317(1-2):1-10.
  15. Thomas VL, Gropper SS. Effect of chromium nicotinic acid supplementation on selected cardiovascular disease risk factors. Biol Trace Elem Res. 1996;55(3):297-305.
  16. Wilson BE, Gondy A. Effects of chromium supplementation on fasting insulin levels and lipid parameters in healthy, non-obese young subjects. Diabetes Res Clin Pract. 1995;28(3):179-84.
  17. Senapati A. Zinc deficiency and the prolonged accumulation of zinc in wounds. Br J Surg. 1985 Jul;72(7):583-4
  18. Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006;72(12):1100-16.
  19. Poeckel D, Tausch L, Altmann A, et al. Induction of central signaling pathways and select functional effects in human platelets by beta-boswellic acid. Br J Pharmacol. 2005;146(4):514-24.
  20. Poeckel D, Boswellic acids: biological actions and molecular targets. Curr Med Chem. 2006;13(28):3359-69

FAQ's

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Healthy Feet & Nerves™

Q: Q. Why have chromium in the formula?

A. Chromium is frequently seen in supplement formulations that focus on blood sugar health concerns, because studies show that it is effective at promoting a healthy insulin response.*

Q: Q. What are chelates?

A. A “chelate” is a bond between a mineral (often called “inorganic”) and a molecule structure, called a “ligand” that helps the body absorb the mineral during digestion. The amino acid glycine makes an excellent molecule to help shepherd minerals through the intestinal wall, because it is so small that it can be transported directly into the cells of the body, so it can get to work right away. The chromium and zinc in this formula are chelated trace minerals that use The Real Amino Acid Chelate System, known as TRAACS®.

Q: Q. Why is ‘high-AKBA’ important when you’re talking about boswellia?

A. Because not all boswellia extracts are the same. Healthy Feet and Nerves provides BosPure® boswellia. BosPure provides at least 10% or more of the compound acetyl-11-keto-β-boswellic acid (AKBA), which is known for its ability to support the body’s own healthy inflammation response.* However, not every compound in boswellia is associated with beneficial effects, so BosPure is also screened to reduce beta-boswellic acid content to less than 5%. By doing this, BosPure has up to twice the power of standard boswellia extracts.*

Did You Know?

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Healthy Feet & Nerves™

The boswellia tree is native to India. It grows in very harsh, dry environments. When the bark of the tree is scraped, it secretes a resin called “tears.” These tears are better known as frankincense. Boswellic acid extracted from the tears of the boswellia tree has been used in Ayurvedic medicine for hundreds of years.

Testimonials

Healthy Feet & Nerves™

Supports Healthy Nerve Function in the Feet and Throughout the Body*

Product Number: 34206 - 60 Capsules

Dietary Supplement

1-2 tablets daily, for optimal benefits may increase to
3 tablets daily.

This combination of bioactive B6 and B12, methylfolate, alpha lipoic acid, BosPure® boswellia, and highly absorbable chromium chelate provides nutrient support for activity and comfort.*

• Supports healthy nerve function in the feet,
   hands, and throughout the body
• Aids proper blood circulation
• Supports healthy blood sugar metabolism*

SUPPLEMENT FACTS

Serving Size: 1 Tablet

Servings Per Container: 60 Tablets Amount/Serving Daily Value

Thiamin (B1) (as Thiamine HCl)

 25 mg 1,667%

Riboflavin (Vitamin B2)

 25 mg 1,471%

Niacin (Vitamin B3)

 10 mg 50%

Vitamin B6 (as Pyridoxal-5-Phosphate)

 30 mg 1,500%

Folate

 250 mcg 63%

(as (6S)-5-methylfolate) (equivalent to 500 mcg of (6S)-5-Methyltetrahydrofolic acid, glucosamine salt)†

Vitamin B12 (as Methylcobalamin)

 500 mcg 8,333%

Biotin

 1 mg 333%

Pantothenic acid
(as D-Calcium Pantothenate)

 200 mg 2,000%

Zinc

 10 mg 67%

(as TRAACS® Zinc Glycinate Chelate)

Chromium

 200 mcg 167%

(as TRAACS® Chromium Nicotinate Glycinate Chelate)

Alpha Lipoic Acid

 200 mg **

Boswellia (Boswellia serrata)
Gum Resin Extract

 100 mg **

(BosPure® standardized to contain >70% boswellic acids with AKBA >10% with less than 5% beta-boswellic acids)

** Daily Value (DV) not established
† US Patent No. 7,947,662

Other Ingredients: Cellulose, croscarmellose sodium, silicon dioxide, vegetable source magnesium stearate, ethylcellulose (modified cellulose).

Contains no: sugar, salt, soy, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, or preservatives.

VEGAN

BosPure® is a registered trademark of Dolcas-Biotech
TRAACS® is a registered trademark of Albion Laboratories, Inc.

If pregnant or nursing, consult a health care practitioner before using.

Made in the USA

Europharma

*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION.
THESE PRODUCTS ARE NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT DISEASE.

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