Evidence
(How it Works)

OsteoStrong™

Bone is living tissue, requiring intake of many different nutrients. OsteoStrong™ contains a blend of key nutrients specifically selected for their ability to promote optimal bone development. OsteoStrong features high levels of vitamin D, one of the most important nutrients for bone health.*

Vitamin D3
Vitamin D promotes proper calcium absorption in the intestines, and aids in bone growth and healthy bone development.*^1-3

Vitamin K
Vitamin K aids in the formation of proteins (osteocalcin, matrix Gla protein, and protein S) which promote bone mineralization and bone development.*^4,5

Calcium
About 99% of calcium in the body is found in bones and teeth, where it provides structure and rigidity.*^6,7

Magnesium
The process of bone mineralization refers to the process by which the body uses minerals to build bones. Magnesium is an important part of mineralization, along with calcium and phosphorus.*^8,9

Zinc
Zinc’s role in bone formation is not well understood. However, research has increasingly connected zinc intake with bone health.*¹⁰

Copper
Copper (along with zinc) is an essential cofactor for enzymes involved in the synthesis of bone matrix constituents.*¹¹

Manganese
Manganese is an essential nutrient for bone formation.*¹²

Boron
Boron is important for bone health through its effects on calcium metabolism.*^13,14

Vitamin K-2
Vitamin K-2 helps support bone mineralization and supports the healthy deposit of calcium in bones.*^15,16

Lactobacillus sporogenes (Bacillus coagulans)
Lactobacillus sporogenes yields lactic acid. A more acidic environment in the intestines promotes greater mineral absorption, particularly of calcium.*^17,18

Silicon
Silicon is involved in bone formation through the synthesis and/or stabilization of collagen, which aids in resilience of bone and connective tissue.*¹⁹

References

^{1. Stechschulte SA, Kirsner RS, Federman DG. Vitamin D: bone and beyond, rationale and recommendations for supplementation. Am J Med. 2009;122(9):793-802.}

^{2. Holick MF. The role of vitamin D for bone health and fracture prevention. Curr Osteoporos Rep. 2006;4(3):96-102.}

^{3. Holick MF. Optimal vitamin D status for the prevention and treatment of osteoporosis. Drugs Aging. 2007;24(12):1017-29.}

^{4. Bügel S. Vitamin K and bone health in adult humans. Vitam Horm. 2008;78:393-416.}

^{5. Bolton-Smith C, McMurdo ME, Paterson CR, et al. Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. J Bone Miner Res. 2007;22(4):509-19.}

^{6. Nordin BE. Calcium and osteoporosis. Nutrition. 1997;13(7-8):664-86.}

^{7. Cashman KD. Calcium intake, calcium bioavailability and bone health. Br J Nutr. 2002;87 Suppl 2:S169-77.}

^{8. Ryder KM, Shorr RI, Bush AJ, et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc. 2005;53(11):1875-80.}

^{9. Rude RK, Singer FR, Gruber HE. Skeletal and hormonal effects of magnesium deficiency. J Am Coll Nutr. 2009;28(2):131-41.}

^{10. Hyun TH, Barrett-Connor E, Milne DB. Zinc intakes and plasma concentrations in men with osteoporosis: the Rancho Bernardo Study. Am J Clin Nutr. 2004;80(3):715-21.}

^{11. Lowe NM, Lowe NM, Fraser WD, Jackson MJ. Is there a potential therapeutic value of copper and zinc for osteoporosis? Proc Nutr Soc. 2002;61(2):181-5.}

^{12. Bae YJ, Kim MH. Manganese supplementation improves mineral density of the spine and femur and serum osteocalcin in rats. Biol Trace Elem Res. 2008l;124(1):28-34.}

^{13. Nielsen FH. Studies on the relationship between boron and magnesium which possibly affects the formation and maintenance of bones. Magnes Trace Elem. 1990;9(2):61-9.}

^{14. Volpe SL, Taper LJ, Meacham S. The relationship between boron and magnesium status and bone mineral density in the human: a review. Magnes Res. 1993;6(3):291-6.}

^{15. Koitaya N, Ezaki J, Nishimuta M, et al. Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women. J Nutr Sci Vitaminol (Tokyo). 2009;55(1):15-21.}

^{16. Iwamoto J, Takeda T, Sato Y. Role of vitamin K2 in the treatment of postmenopausal osteoporosis. Curr Drug Saf. 2006;1(1):87-97.}

^{17. Chonan O, Takahashi R, Yasui H, Watanuki M. Effect of L-lactic acid on the absorption of calcium in gastrectomized rats. J Nutr Sci Vitaminol (Tokyo). 1998;44(6):869-75.}

^{18. Sheikh MS, Santa Ana CA, Nicar MJ, Schiller LR, Fordtran JS. Gastrointestinal absorption of calcium from milk and calcium salts. N Engl J Med. 1987;317(9):532-6.}

^{19. Jugdaohsingh R. Silicon and bone health. J Nutr Health Aging.} ^{2007r;11(2):99-110.}

Did You Know?

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OsteoStrong™

Bones are rigid, living tissue that support and protect the organs of the human body. Adult humans have 206 bones. The femur, or thighbone, is the largest. The smallest is the stirrup bone in the middle ear, at about 1/10 of an inch long. Bones are made of protein, minerals (calcium, potassium, manganese, magnesium, silica, iron, zinc, boron, and more) and vitamins. By the age of 20, the average person has acquired 98% of their skeletal mass. However, weight bearing exercises, proper nutrition, and the use of the appropriate dietary supplements can help keep bones healthy at any time of life.

OsteoStrong™

Maintains Strong Healthy Bones*

Product Number: 10702 - 120 Tablets

Dietary Supplement

4 tablets daily. May be taken as 2 tablets in the a.m. and 2 tablets in the p.m.

Bone is exceptional living tissue and requires much more than just calcium.
Bone requires a variety of nutrients including vitamins, minerals, amino acids and trace minerals. OsteoStrong™ is a unique proprietary product that contains all the necessary nutritional components to maintain strong, healthy bones. Calcium, vitamin D, vitamin K and boron help maintain bone structure. With OsteoStrong, you will be protecting your bones for life.*

SUPPLEMENT FACTS

Serving Size: 4 Tablets

Servings Per Container: 30	Amount/Serving	Daily Value
Vitamin D-3 (Cholecalciferol)	4000 IU	1000%

Vitamin K-1 (as phytonadione)	300 mcg	424%

Calcium (as citrate and malate)	450 mg	36%

Magnesium (as chelate)	200 mg	48%

Zinc (as chelate)	20 mg	132%

Copper (as chelate)	2 mg	100%

Manganese (as chelate)	2 mg	100%

Boron (Fructo-borate)	12.5 mg	**

Vitamin K-2	45 mcg	**
(Natto Extract MenaQ7™ menaquinone-7)
Lactobacillus Sporogenes	1 billion	**
(Bacillus coagulans, lactic acid bacteria)
Silicon (as sodium metasilicate)	50 mg	**
^{**Daily Value Not Established.}

Other Ingredients: cellulose, modified cellulose, magnesium stearate, glaze Contains Soy† (less than 5 parts per million)

Contains no: sugar, salt, yeast, wheat, gluten, corn, artificial coloring, artificial flavoring or preservatives. It contains only natural ingredients. Color variations are normal.

^{† All EuroPharma products are actually free of soy. We list “contains soy” if a formula contains phospholipids, nattokinase and vitamin K2 which are extracted from soy. The chance of these healthy ingredients causing a risk of allergies is extremely low or non-existent. They contain a possible soy content in parts per million. However, for the safety and comfort of our customers, we provide soy information.}

If pregnant or nursing, consult a health care practitioner before using.

Made in the USA

Evidence
(How it Works)

OsteoStrong™

Did You Know?

OsteoStrong™

OsteoStrong™

Dietary Supplement

SUPPLEMENT FACTS

Printable Literature

EUROPHARMA USA LIBRARY DISCLAIMER

Evidence (How it Works)

OsteoStrong™

Did You Know?

OsteoStrong™

OsteoStrong™

Dietary Supplement

SUPPLEMENT FACTS

Printable Literature

EUROPHARMA USA LIBRARY DISCLAIMER

Evidence
(How it Works)