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Because of its role as a co-factor (or assistant) to over a 100 different enzymes, vitamin B6 levels have an impact on many body systems that would seem unrelated at first glance.1 P-5-P with Magnesium contains this crucial vitamin in its most absorbable form – pyridoxal-5-phosphate, or P-5-P.  This formula is ideal for healthy joint support, supporting mood and relieving stress, promoting healthy fluid balance, and more. The addition of magnesium promotes optimal P-5-P absorption and aids in cellular energy production and support of many health systems.3

Vitamin B6: Pyridoxal-5-Phosphate (P-5-P):  Low levels of vitamin B6, especially the active coenzyme form, pyridoxal-5-phosphate found naturally in the blood, may be a factor in serotonin production and other reactions in the body that determine mood and nervous system function.1,2 Randomized, double-blind, placebo controlled clinical studies have also shown that vitamin B6 can help relieve stress associated with premenstrual syndrome.3 It is also considered a strong supporter of healthy muscle function, especially for individuals working in tasks requiring repetitive movement.*4,5

Magnesium: (as magnesium glycinate chelate) Magnesium is involved with the production of cellular energy throughout the body. It supports thyroid health and hormone production, bone metabolism, and healthy blood pressure levels already within normal limits.*6-9 Magnesium in its chelated form is highly absorbable and aids in the absorption of pyridoxal-5-phosphate.


  1. Vitamin B6. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:639.
  2. Bartel PR, Ubbink JB, Delport R, Lotz BP, Becker PJ. Vitamin B-6 supplementation and theophylline-related effects in humans. Am J Clin Nutr. 1994;60(1):93-9.
  3. Magnesium. In: Hendler SS, ed. PDR for Nutritional Supplements. 2nd ed. Montvale, NJ: Physician’s Desk Reference; 2008:404-409.
  4. Ellis JM, Folkers K, Levy M, Shizukuishi S, Lewandowski J, Nishii S, Schubert HA, Ulrich R. Response of vitamin B-6 deficiency and the carpal tunnel syndrome to pyridoxine. Proc Natl Acad Sci U S A. 1982;79(23):7494-8.
  5. Keniston RC, Nathan PA, Leklem JE, Lockwood RS. Vitamin B6, vitamin C, and carpal tunnel syndrome. A cross-sectional study of 441 adults. J Occup Environ Med. 1997;39(10):949-59.
  6. Ebadi M. Regulation and function of pyridoxal phosphate in CNS. Neurochem Int. 1981;3(3-4):181-205.
  7. Cinar V. The effects of magnesium supplementation on thyroid hormones of sedentars and Tae-Kwon-Do sportsperson at resting and exhaustion. Neuro Endocrinol Lett. 2007;28(5):708-12.
  8. Corradino RA, Parker HE. Magnesium and thyroid function in the rat. J Nutr. 1962;77:455-458.
  9. Houston MC, Harper KJ. Potassium, magnesium, and calcium: their role in both the cause and treatment of hypertension. J Clin Hypertens (Greenwich). 2008;10(7 Suppl 2):3-11.


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Q: I’ve heard that magnesium can cause diarrhea. What makes this one different?

Like all supplemental ingredients, absorption is the key. Because magnesium glycinate chelate is more easily absorbed and used by the body, less remains unabsorbed in the intestines. Magnesium attracts water, so if it is not well-absorbed, it can cause loose stools. Because magnesium glycinate is so well-absorbed, this is not a problem.

Q: Can P-5-P/Mag help with PMS?

Absolutely. Not only has P-5-P been shown to reduce premenstrual tension, it relieves water retention and bloating.

Did You Know?

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The term “vitamin B6” is actually a generic name for three related forms of the vitamin: pyridoxine, pyridoxal, and pyridoximine. The form used in P-5-P/Mag™ is the pyridoxal-5-phosphate form, which is involved in much of the body’s chemical reactions.


Bio-Active Vitamin B6 and Magnesium

Product Number: 26106 - 60 Capsules

Product Number: 26102 - 120 Capsules

Dietary Supplement

1 capsule daily with food, or up to 4 per day. 6-12 year olds, 1 per day.

Pyridoxal-5-phosphate (P-5-P) is the active form of Vitamin B6. Unlike other forms it does not require conversion by the liver. Chelated magnesium promotes P-5-P metabolism.

• Significant benefits for heart health
• Aids tendon, ligament and cartilage function
• Supports healthy muscles and protein metabolism
• Supports serotonin and dopamine formation
• Supports nervous system function in children and adults*


Serving Size: 1 Capsule

Servings Per Container: 60 or 120 Capsules Amount/Serving Daily Value

Vitamin B6 (as pyridoxal-5-phosphate)

30 mg 1,500%

Magnesium (as magnesium glycinate chelate)

100 mg 25%

Other Ingredients: hydroxypropyl methylcellulose (vegetable cellulose capsules), cellulose powder, silicon dioxide, and vegetable source magnesium stearate.

No: sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, or artificial preservatives.

If pregnant or nursing, consult a health care practitioner before using.

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The research articles and study abstracts that you are about to view in the EuroPharma USA Library were prepared by independent authors and researchers. They are being reproduced on this site in their entirety. No such article or study abstract is intended to promote a particular manufacturer or brand of dietary supplement. This information is not intended to replace the advice of your health care practitioner. If you have any medical conditions, or are taking any prescription or nonprescription medications, see your physician and discuss all aspects of your treatment before altering or discontinuing any course of therapy. Accordingly, individuals must necessarily assume responsibility for their own actions, safety, and health, and the company is not liable or responsible for any loss, injury, or damage allegedly arising from any information posted on this cite.