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Evidence
(How it Works)

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How it Works:

Pomegranate has long been recognized for its benefits. It has become even more popular in recent years as a “superfood”. Pomegranate has been studied for its support of cardiovascular, cellular, antioxidant, immune, and joint health.* 1-19

However, there are many nutrients throughout the entire fruit, some of which are best available in supplemental form.*

Pomegranate seed extract and pomegranate seed oil extract provide a complete range of valuable nutrients for many benefits. PomXtra™ contains two types of pomegranate extract. It includes a supercritical extraction of the oil of the seed, which is rich in punicic acid, which is then blended in a polyphenol-rich seed extraction for double the benefits. This unique combination is what makes PomXtra™ able to support a variety of health concerns.*

Aside from targeted nutrient power, a strong pomegranate extract like PomXtra™ is also more convenient; just two softgels provide the antioxidant activity of 14 ounces of juice.

References

  1. Jurenka JS. Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev. 2008 Jun;13(2):128-44.
  2. Aviram M, Dornfeld L, Rosenblat M, et al. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregations: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr. 2000;71:1062-1076.
  3. Kaplan M, Hayek T, Raz A, et al. Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J Nutr. 2001;131:2082-2089.
  4. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure, and LDL oxidation. Clin Nutr 2004;23:423-433.
  5. Sumner MD, Elliott-Eller M, Weidner G, et al. Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease. Am J Cardiol 2005;96:810-814.
  6. Adhami VM, Khan N, Mukhtar H. Cancer chemoprevention by pomegranate: laboratory and clinical evidence. Nutr Cancer. 2009 Nov;61(6):811-5. 
  7. Pantuck AJ, Zomorodian N, Belldegrun AS. Phase-II Study of pomegranate juice for men with prostate cancer and increasing PSA. Curr Urol Rep. 2006 Jan;7(1):7.
  8. Kim ND, Mehta R, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat. 2002 Feb;71(3):203-17.
  9. Mehta R, Lansky EP. Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture. Eur J Cancer Prev. 2004 Aug;13(4):345-8.
  10. Toi M, Bando H, Ramachandran C, Melnick SJ, Imai A, Fife RS, Carr RE, Oikawa T, Lansky EP. Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo.  Angiogenesis. 2003;6(2):121-8.
  11. Guo C, Wei J, Yang J, et al. Pomegranate juice is potentially better than apple juice in improving antioxidant function in elderly subjects. Nutr Res. 2008;28:72-77.
  12. Gil MI, Tomás-Barberán FA, Hess-Pierce B, Holcroft DM, Kader AA. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem. 2000 Oct;48(10):4581-9.
  13. Menezes SM, Cordeiro LN, Viana GS. Punica granatum (pomegranate) extract is active against dental plaque. J Herb Pharmacother 2006;6:79-92.
  14. Vasconcelos LC, Sampaio MC, Sampaio FC, Higino JS. Use of Punica granatum as an antifungal agent against candidosis associated with denture stomatitis. Mycoses 2003;46:192-196.
  15. Braga LC, Shupp JW, Cummings C, et al. Pomegranate extractinhibits Staphylococcus aureus growth and subsequent enterotoxin production, J. Ethnopharmacol., 2005, 96:335-39.
  16. Braga C, Leite AA, Xavier KB, et al. Synergic interaction between pomegranate extract and antibiotics against Stalhylococcvus aureus, Can. J. Microbiol., 2005, 51:541-47.
  17. Neurath AR, Strick N, Li YY, et al. Punica granatum (Pomegranate) juice provides HIV-1 entry inhibitor and candidate topical microbicide, BMC Infect. Dis., 2004, 4:41. 
  18. Ahmed S, Wang N, Hafeez BB, Cheruvu VK, Haqqi TM. Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro. J Nutr. 2005 Sep;135(9):2096-102.
  19. Shukla M, Gupta K, Rasheed Z, Khan KA, Haqqi TM. Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis. Nutrition. 2008 Jul-Aug;24(7-8):733-43.

 

FAQ's

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Q: Why two types of pomegranate extract?

Both pomegranate seed and seed oil are rich in polyphenols, conjugated linolenic acid, punicic acid, and phytosterols. By including both extracts, PomXtra™ provides a more complete range of supportive compounds – more than you could likely get from juice alone. In fact, pomegranate seed and seed oil extracts show some of the strongest support for
breast and prostate cellular health.*

Q: How can 2 softgels provide as much antioxidant and cell-protecting power as a 14-ounce glass of pomegranate juice?

Because these extracts are so concentrated, they are able to focus the powerful benefits of pomegranate into a much smaller package. Plus, the seed oil extract is rich in punicic acid, which shows strong support of breast and prostate cell health. This compound may not be present in the same concentrated power in many juice products.*

Q: What is “supercritical CO2 extraction” and why does it matter? Is it natural?

Many supplemental ingredients are produced using harsh solvents such as hexane to separate the oil from the plant material in order to concentrate its benefits. Supercritical CO2 extraction uses a different method.

It uses carbon dioxide in liquid form, which is odorless, tasteless, and non-toxic. Oils in plants that are extracted using this method contain no heavy metals, are completely pure and safe, provide no base for germ growth or need preservation. Supercritical CO2 extraction works at very low temperatures, preserves sensitive plant constituents, and avoids the risk of biologically active components being destroyed by oxidation. CO2 extracts are 100% natural, authentic, highly concentrated and offer the user the highest level of key active constituents that are found in the plant or oil.

Q: What about soy in this product? Is that something I need to worry about?

PomXtra™ contains soy lecithin, which is present as an excipient. Excipients are those ingredients in a product that do not play an active therapeutic role, yet are essential to creating effective products.

The chance of the soy found in PomXtra™ causing a risk of allergies is extremely low or non-existent, as the actual amount of soy protein is very low (it is only present in parts per million). Allergies to soy are often associated with soy protein, not soy lecithin. However, because it is of concern to some of our customers, we provide soy information even if the amount in the product is miniscule.

Did You Know?

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Pomegranates (Punica granatum) have been revered by cultures ancient and modern, from the Mediterranean to India and China. They’re even mentioned in the Old Testament, being a featured decorative motif in the temple of King Solomon. Pomegranate trees were one of the first to be cultivated, dating back as far as 3,000 BC. Their popularity ensured their success, and soon they spread throughout the Middle East from their beginnings further north, probably near the Caucasus region along northern Turkey, Iraq, and Iran.

PomXtra™

Breast, Prostate, Colon, and Heart Health

Health Benefits of Juice in a Convenient Softgel

HIGH ANTIOXIDANT VALUE
2 Softgels = 14 oz. Juice†

Convenient. No Sugar. High in Antioxidants. No Calories

Product Number: 15006 - 60 Softgels

Dietary Supplement

1 softgel, once or twice daily.

Pomegranate provides a complete range of valuable nutrients for many benefits. However, pomegranate juice drinks are often high in sugar and it can be difficult to drink enough pomegranate juice to achieve optimal health benefits.

Every health system in the body relies on antioxidants for optimal function. PomXtra™ provides antioxidant and cell-protecting power in a
convenient softgel. This unique formulation contains two types of pomegranate extract: Seed Oil – rich in punicic acid – and Seed Extract – rich in polyphenols. This unique combination is what gives PomXtra™ its extra benefits.

PomXtra™ is the high antioxidant choice for:

Breast and Prostate Health
Colon Health
Healthy LDL-Cholesterol Balance
Protection from Free-Radical Damage
Hormone Balance
Healthy Aging
Cartilage and Joint Support
Heart Health
Artery Strength*


CELL PROTECTING POWER*

SUPPLEMENT FACTS

Serving Size: 1 Softgel

Servings Per Container: 60 Amount/Serving Daily Value

Proprietary Blend

600 mg **

Containing Organic Pomegranate (Punica granatum) Seed Oil by Supercritical extraction standardized to contain > 60% punicic acid, Pomegranate (Punica granatum) Seed Extract standardized for > 60% polyphenols

Other Ingredients: gelatin, glycerin, yellow beeswax, purified water, soy lecithin, silica, annatto suspension in sunflower oil. Contains Soy (less than 5 parts per million)

No: sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, or preservatives.

NON-GMO

† Antioxidant activity

If pregnant or nursing, consult a health care practitioner before using.

Made in the USA

Europharma

EUROPHARMA USA LIBRARY DISCLAIMER

The research articles and study abstracts that you are about to view in the EuroPharma USA Library were prepared by independent authors and researchers. They are being reproduced on this site in their entirety. No such article or study abstract is intended to promote a particular manufacturer or brand of dietary supplement. This information is not intended to replace the advice of your health care practitioner. If you have any medical conditions, or are taking any prescription or nonprescription medications, see your physician and discuss all aspects of your treatment before altering or discontinuing any course of therapy. Accordingly, individuals must necessarily assume responsibility for their own actions, safety, and health, and the company is not liable or responsible for any loss, injury, or damage allegedly arising from any information posted on this cite.

THIS INFORMATION IS BEING PRESENTED PURSUANT TO SECTION 5 OF THE DIETARY SUPPLEMENT HEALTH AND EDUCATION ACT OF 1994-------THE "E" IN DSHEA—BROUGHT TO YOU AS A PUBLIC SERVICE BY EUROPHARMA USA.